Genentech, Inc.

F. Hoffmann-la Roche Ag

Alberto Gobbi

Benjamin Fauber

Monique Bodil Van Niel

Stuart Ward

Olivier Rene

Christopher Hurley

Emanuela Gancia

Naomi S Rajapaksa

Joy Drobnick

David Robert Vesey

Marian C Bryan

James Richard Kiefer, Jr

Paul Winship

Simon Gaines

Jun Liang

Andrew Peter Cridland

Jonathan Killen

Tammy Ladduwahetty

Tamiko Katsumoto

Fei Wang

Alan G Olivero

Steven Huy Do

Aleksandr Kolesnikov

Jianwen A Feng

Chudi Obioma Ndubaku

Wendy Lee

James John Crawford

Kwong Wah Lai

Jason R Zbieg

David Nigel Hurst

Zhiguo Liu

Sarah Bronner

Yongsheng Chen

John Wai

Patrick Cyr

Liqiang Fu

Robert Maxey

Tammy Laddywahetty

Naomi Rajapaksa

Andrew Cridland

David Vesey

David Hurst

Compounds of Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI, Formula VII, Formula VIII, and methods of use as Interleukin-1 Receptor Associated Kinase (IRAK4) inhibitors are described herein.

Pyrazolo[ 1,5a]pyrimidine derivatives as IRAK4 modulators

Compounds of formula I: or pharmaceutical salts thereof,wherein m, n, p, q A, B, R, R, R, R, R, Rand Rare as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Pyridazine derivatives as RORc modulators

Compounds of Formula 0, Formula I, and Formula II and methods of use as Interleukin-1 Receptor Associated Kinase (IRAK4) inhibitors are described herein.

Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators

Compounds of Formula 0, and stereoisomers and pharmaceutically acceptable salts thereof, as well as methods of use as Interleukin-1 Receptor Associated Kinase (IRAK4) inhibitors are described herein.

IRAK4 modulators

Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, X, X, X, X, Y, Z, A, R, R, R, R, RR, R, R, R, R, R, Rand Rare as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis, muscular sclerosis and psoriasis.

Aryl sultam derivatives as RORc modulators

Compounds of the formula I: or a pharmaceutical salt thereof,wherein X, Ar, R1, R, R, R, R, Rand Rare as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Compounds of the formula I: or pharmaceutically acceptable salts thereof,wherein m, n, p, q, r, A, W, X, X, X, X, Y, Z, R, R, R, R, R, R, R, R, R, R, Rand Rare as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Compounds of the formula I or II: or pharmaceutically acceptable salts thereof, wherein Ris a group of formula (a), (b), (c); (d) or (e): and m, n, X, Y, R, R, R, R, Rand Rare as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Keto-imidazopyridine derivatives as RORc modulators

Compounds of the formula I: or pharmaceutically acceptable salts thereof,wherein m, n, p, q, r, A, W, X, X, X, X, Y, Z, R, R, R, R, R, R, R, R, R, R, R, and Rare as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of inflammatory diseases such as arthritis.

Growing community of inventors

South San Francisco, CA, United States of America

Alberto Gobbi