Bioresearch, Inc.

Alberto Fiecchi

Stable salts of S-adenosil-L-methionine (SAM) with sulphonic acids chosen from the group consisting of methanesulphonic, ethanesulphonic, 1-n-dodecanesulphonic, 1-n-octadecanesulphonic, 2-chloroethanesulphonic, 2-bromoethanesulphonic, 2-hydroxyethanesulphonic, 3-hydroxypropanesulphonic, d-, 1, -d, 1-10-camphorsulphonic, d-, 1-, d, 1-3-bromocamphor-10-sulphonic, cysteic, benzenesulphonic, p-chlorobenzenesulphonic, 2-mesitylbenzenesulphonic, 4-biphenylsulphonic, 1-naphthalenesulphonic, 2-naphthalenesulphonic, 5-sulphosalicylic, p-acetylbenzenesulphonic, 1,2-ethanedisulphonic, o-benzenedisulphonic and chondroitinesulphuric acids, and double salts of said acids with sulphuric acid.

Sulphonic acid salts of S-adenosilmethionine

Double salts of S-adenosyl-L-methionine are prepared by the action of the enzyme ATP-methionine-adenosyltransferase on a mixture of adenosine triphosphate and methionine and subsequently precipitating said double salts with picrolonic acid, p-toluenesulphonic acid, sulphuric acid and organic solvents.

Process of preparing double salts of S-adenosyl-L-methionine

New double salts extremely stable of S-Adenosil-L-methionine with sulphuric acid and p.toluensulphonic acid of the formula SAM.sup.+.HSO.sub.4 .sup.-.H.sub.2 SO.sub.4.2CH.sub.3 C.sub.6 H.sub.4 SO.sub.3 H and SAM.sup.+.HSO.sub.4 .sup.-.H.sub.2 SO.sub.4.CH.sub.3 C.sub.6 H.sub.4 SO.sub.3 H, process for the preparation thereof and therapeutic compositions containing them.

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Milan, Italy

Alberto Fiecchi