Instituto Biochimico Italiano Giovanni Lorenzini S.p.a.

Snamprogetti S.p.a.

Istituto Biochimico Italiano Giovanni Lorenzini S.p.a.

Alberto Brandt

Giordano Bruno Corsi

Loredana Cecchetelli

Luciano Re

Fabio Carli

Luciano Bassignani

Fabio Borella

Antonio Simeoni

The present invention refers to the preparation process of the sodium salt of 6&lsqb;D-(&minus;)&agr;-4-(ethyl-2,3-dioxo-1-piperazinocarbonylamino) phenylacetamido&rsqb;penicillanic acid, comprising the reaction of the acid with a reagent selected from the group consisting of sodium hydroxide, sodium carboxylates and sodium alcoholates, followed by a separation step of the so obtained sodium salt by precipitation.

Process for the preparation of the sodium salt of 6&lsqb;D-(-)&agr;-4-(ethyl-2,3-dioxo-1-piperazinocarbonylamino)phenylacetamido&rsqb;penicillanic acid

A process for the preparation of sterile sodium amoxycillin characterized by the fact that a solution of amoxycillin trihydrate in a mixture of methyl alcohol and a lower C.sub.2 -C.sub.5 alcohol is reacted in a sterile ambient, optionally in the presence of a suitable amine, with a solution of a suitable salifying agent selected from the group consisting of an alcoholate or carboxylate of sodium in methyl acetate followed by separation of the precipitate is described.

Process for the preparation of sterile amoxycillin sodium salt

A slow-release pharmaceutical composition containing a bile acid as active ingredient and comprising at least one bioadhesive substance and at least one high specific gravity substance, an aliquot thereof being enteric coated and the remainder being non-enteric coated.

Slow release pharmaceutical composition containing a bile acid as an

An operationally simple and economical process for preparing alpha-oxoesters is provided by reacting an acetylenic compound of formula

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Alberto Brandt