National Foundation for Cancer Research

Albert Szent-Gyorgyi

Gabor B Fodor

Novel 2-furylbutyrolactones are directly formed by reaction of 2,5-dialkoxy-2,5-dihydrofurans and 2,3-dihydroxybutenolides in aqueous media and recovering crystalline product from an anhydrous medium. These novel compounds and compositions containing same may be used for lymophocyte stimulation.

2-furylbutyrolactones and methods for using same

Novel cyclic acetals of the general formulae: ##STR1## wherein R.sub.1 is ##STR2## wherein R.sub.2 is hydrogen, alkyl, aryl or R.sub.1, wherein R.sub.3 through R.sub.10 are hydrogen, alkyl or aryl, wherein R.sub.5 and R.sub.6 together may form .dbd.O, wherein X is hydrogen, alkyl, cycloalkyl, aryl, hydroxyaryl or arylakyl, or wherein R.sub.8 is ##STR3## are described. Said compounds are prepared by mixing approximately equimolar amounts of the appropriate aldehyde or ketone, and enediol compound, and allowing same to react in aqueous solution under a nitrogen atmosphere. Compositions containing these novel compounds exhibit hypotensive and analgesic properties and are useful in the treatment of hypertension and pain in animals and humans.

Hypotensive and analgesic compounds and compositions and methods for

Novel chemical compounds of the general formulae: ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen, alkyl, cycloalkyl, aryl or arylalkyl, wherein R.sub.3 through R.sub.10 are hydrogen, alkyl, or aryl, wherein R.sub.5 and R.sub.6 together may form .dbd.0, and wherein X is hydroxy. The compounds are prepared by mixing specified amounts of a dialdehyde, .alpha.-keto-aldehyde, or diketone, such as methylglyoxal or a related compound, and an enediol, such as L-ascorbic acid or a compound that can be converted into an enediol, such as an acyloin, and allowing same to react under a nitrogen atmosphere in the presence of a non-interfering solvent. Compositions containing these novel compounds exhibit cytostatic, hypotensive and analgesic properties and are useful in the treatment of cancer in animals and humans.

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Woods Hole, MA, United States of America

Albert Szent-Gyorgyi