Merrell Dow Pharmaceuticals

Richardson-merrell Inc.

Merrell Pharmaceuticals, Inc.

Merrell Toraude Et Compagnie

Albert Sjoerdsma

Peter P McCann

Alan J Bitonti

Philippe Bey

Michael L Edwards

Michel Jung

Fritz E Gerhart

David M Stemerick

Daniel Schirlin

Patrick J Casara

Peter P Mccann

This invention relates to certain polyamine derivatives, to the methods and intermediates useful for their preparation, and to their use in treating diseases caused by infestation with a variety of parasitic protozoa.

Polyamine derivatives

Drug-resistant malarial infection in humans can be effectively treated with standard antimalarial agents if administered in conjunction with desipramine.

Despiramine in the treatment of drug-resistant malarial infections

Red blood cells which are infected with the parasite P. falciparum cause the cells to become sticky and less deformable. This results in a build-up of cells on the vascular wall and creates occlusions to blood flow which are thought to cause the cerebral, renal and liver complications of P. falciparum infections. Certain esters of castanospermine prevent or reduce the adhesion of falciparum infected blood cells to the vascular endothelial wall and are a useful adjunct in the treatment of malaria.

Esters of castanospermine in the treatment of cerebral malaria

This invention relates to the use of .alpha.- halomethyl, .alpha.-acetylenic or .alpha.-allenic derivatives of arginine and agmatine, or their dehydro analogs, in the treatment of Chagas disease and Coccidiosis.

Method of inhibiting protozoal growth

The use of lofexidine and its pharmaceutically acceptable salts in alleviating the adverse symptoms of drug withdrawal, pre-menstrual tension and peri-menopausal flushing is disclosed.

Method of alleviating withdrawal symptoms

The use of lofexidine and its pharmaceutically acceptable salts in alleviating the adverse symptoms of tobacco withdrawal is disclosed.

.alpha.-Substituted amines are described which are useful in controlling the growth of algae.

Method of inhibiting algae

Fluorinated diaminobutane derivatives

.alpha.-Substituted amines and .alpha.-substituted-.alpha.-amino acids are described which are useful in inhibiting the growth of protozoa in animals.

Method of inhibiting the growth of protozoa

The use of lofexidine and its pharmaceutically acceptable salts in alleviating the adverse symptoms of drug withdrawal is disclosed.

.alpha.-Substituted amines and .alpha.-substituted-.alpha.-amino acids are described which are useful in controlling the growth of algae.

Therapeutic antihypertensive compositions containing N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine and N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzenemethanamine or their non-toxic, pharmaceutically acceptable salts are described as well as a method of reducing blood pressure in mammals.

Antihypertensive compositions of

Therapeutic antihypertensive compositions containing 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole and N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzenemethanamine or their non-toxic, pharmaceutically acceptable salts are described as well as a method of reducing blood pressure in mammals.

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Cincinnati, OH, United States of America

Albert Sjoerdsma