The Hong Kong Polytechnic University

Albert S Chan

Jing Wu

Rongwei Guo

Gang Chen

Jianxin Ji

Jian-Xin Ji

Method of asymmetrically hydrosilylating substrates using catalysts having a ligand of the compound of the formula (I) wherein

Method for asymmetric hydrosilylation of ketones

The present invention provides bipyrimidinyl diphosphine compounds of the formula wherein The compounds of the formula (I) are chiral atropisomeric bipyrimidinyl diphosphine compounds and, thus, may be employed as ligands to generate chiral transition metal catalysts which may be applied in a variety of asymmetric reactions, e.g., in palladium catalyzed asymmetric allylic substitution reactions. The compounds of the present invention are easily accessible in high enantiomeric purity according to the methods disclosed herein.

Chiral tertiary aminoalkylnaphthols

Method for the preparation of asymmetric alkynylated &#x3b1;-amino esters of the formula  wherein Rand Rare independently optionally substituted alkyl cycloalkyl, aryl or heteroaryl, and Y is hydrogen or a nitrogen protecting group.

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Hong Kong, China

Albert S Chan