The University of North Carolina at Chapel Hill

Massachusetts Institute of Technology

Harvard College

Chiron Corporation

Theralogics, Inc.

Other

Whitehead Institute for Biomedical Research

Whitehead Insti.

Albert S Baldwin

James C Cusack

Marty W Mayo

Cun-Yu Wang

Peter Ralph

Phillip A Sharp

John Stephen Haskill

Michael J Lenardo

David Baltimore

Thomas P Maniatis

Chen-Ming Fan

Roger G Clerc

Jonathan H Lebowitz

Louis Staudt

Patrick A Baeuerle

Harinder Singh

Ranjan Sen

Lynn M Corcoran

Denis C Guttridge

Methods for treating muscular wasting diseases such as Duchenne muscular dystrophy are disclosed. Specifically, the methods include administering to a subject in need of treatment for a muscular wasting disease, an NF-&#x3ba;B activation inhibitor capable of blocking the activation of NF-&#x3ba;B.

Methods of treating muscular wasting diseases using NF-KB activation inhibitors

Methods of treating muscular wasting diseases using NF-&#x3ba;B activation inhibitors

The use of NF-&#x3ba;B inhibitors to enhance the cytotoxic effects of chemotherapy or radiation therapy in the treatment of neoplastic conditions is described.

Use of NF-&#x3ba;B inhibition in combination therapy for cancer

The use of NF-&#x3ba;B inhibitors to enhance the cytotoxic effects of chemotherapy or radiation therapy in the treatment of neoplastic conditions is described. When chemotherapeutic compounds and radiation activate NF-&#x3ba;B within cells, the cells are more resistant to the cytotoxic effects of these treatments. Inhibition of NF-&#x3ba;B activation is disclosed to provide a method to improve the efficacy of these cancer therapies.

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The use of NF-&kgr;B inhibitors to enhance the cytotoxic effects of chemotherapy or radiation therapy in the treatment of neoplastic conditions is described.

Use of NF-&kgr;B inhibition in combination therapy for cancer

Constitutive and tissue-specific protein factors which bind to transcriptional regulatory elements of Ig genes (promoter and enhancer) are described. The factors were identified and isolated by an improved assay for protein-DNA binding. Genes encoding factors which positively regulate transcription can be isolated and employed to enhance transription of Ig genes. In particular, NF-kB, the gene encoding NF-kB, IkB and the gene encoding IkB and uses therefor.

Nuclear factors associated with transcriptional regulation

Compositions involving I.kappa.B (i.e., inhibitor of Nuclear Factor-.kappa.B or NF-.kappa.B) and methods of using the same are described that have applications for the identification of prophylactics or therapeutics for the treatment of diseases resulting from altered gene expression, including genes that encode cytokines or related molecules.

Inhibitor of NF-.kappa.B transcriptional activator and uses thereof

Compositions and methods of using the same are described that have applications for the identification of prophylactics or therapeutics for the treatment of diseases resulting from altered gene expression, including genes that encode cytokines or related molecules.

Method of identifying a chemical that alters dissociation of an

DNA and expression vector encoding I.kappa.B Protein

Nuclear factors associates with transcriptional regulation

Growing community of inventors

Chapel Hill, NC, United States of America

Albert S Baldwin