Icagen, Inc.

Albert Michiel Van Rhee

Xiaodong Wang

Kerry Leigh Spear

Michael F Gross

Alan Bradley Fulp

Robert N Atkinson

The present invention provides a genus of bis-benzimidazole compounds, methods and pharmaceutical compositions that are useful as modulators of potassium ion channels. The compounds of the invention are of use in both therapeutic and diagnostic methods.

Bis-benzimidazoles and related compounds as potassium channel modulators

Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides pyrazolopyrimidines, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.

Pyrazolopyrimidine compositions

Pyrazolopyrimidines

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Durham, NC, United States of America

Albert Michiel Van Rhee