Southwest Research Institute

Albert M Zwiener

Darren E Barlow

Joseph A McDonough

Neal K Vail

Joseph T Persyn

Eliot Mark Slovin

Jeffrey Nelson Harris

George Lamberson

Mark R Heistand

Terrence Francis Alger, Ii

Barrett Wade Mangold

Larry Allen Cabell

Kenneth Carson

Richard Michael Corbett

Paul M Thompson

Norma L Cantu

Sandra J Drabik

Andrew P-z Clark

A multi-disk spinning disk assembly for atomization and encapsulation applications. A number of disksand spacers () are stacked to form a disk stackhaving a feed wellin the center core of the stack. The fluid to be atomized or encapsulated is delivered to the feed well. The fluid then flows into spacer channels () within or on the surface of the spacers. The channels () communicate the fluid toward the outer edges of the disks. The disk surface past the spacers () can have various configurations, such as teeth, weirs, or a bigger or smaller diameter, as desired for particular atomization or encapsulation characteristics.

Multi-disk spinning disk assembly for atomization and encapsulation

A multi-disk spinning disk assembly for atomization and encapsulation applications. A number of patterned disks are stacked to form a disk stack having a feed well in the center core of the stack. Each patterned disk has channels defined by spacers, with the channels and spacers being of varying depths, heights, and/or widths. The fluid to be atomized or encapsulated is delivered to the feed well. The fluid then flows into the channels, which communicate the fluid toward the outer edges of the disks. The fluid exits the disk stack from a circumferential gap, which is created by interposing spacing disks between the patterned disks.

Multi-disk spinning disk assembly for atomization and encapsulation with spacing disks for adjusting exit gap

An adapter for delivering an atomized spray from a syringe. The adapter includes an adapter guide including a side wall, an interior surface of the side wall defining a through-bore and a shoulder in the through-bore. A pin guide is located in the through-bore. The pin guide includes a seat and a sleeve extending from the seat. A spring positioned around the pin guide sleeve and between the pin guide seat and the shoulder, wherein the spring and the sleeve provide a passageway there between. A pin extends from the pin guide seat and through the passageway. Affixing the adapter onto a syringe provides an atomizing delivery device. A method of dispensing an atomized spray from a syringe is provided by affixing the adapter to the syringe.

High precision, low dose atomizer

This invention is directed to an apparatus and method for producing microparticles comprising pharmacologically active agents and biodegradable polymers. The apparatus includes a spinning disk containing a reservoir in the center thereof and a flat inclined surface. The apparatus optionally includes serrations and/or a flat surface beneath the periphery of the disk that is parallel to the rotational axis of the disk. The invention is also directed to a method for producing microparticles containing pharmacologically active agents, using the spinning disk apparatus. Formulations containing ophthalmically active agents are provided. Formulations exhibiting zero order release rates are also described.

Biodegradable microparticle pharmaceutical formulations exhibiting improved released rates

The present invention is directed at isoamyl nitrite formulations suitable for use in medicinal applications. The formulations include a composition of isoamyl nitrite in combination with an epoxidized vegetable oil, identified as stabilized isoamyl nitrite. The isoamyl nitrite may also be combined with petrolatum. Methods of treatment of the formulations are applicable to cyanide poisoning, HS poisoning as well as treatment for elevated blood pressure.

Isoamyl nitrite formulations

Methods for preparing biodegradable microparticle formulations containing pharmaceutically active agents

Apparatus for preparing biodegradable microparticle formulations containing pharmaceutically active agents

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Helotes, TX, United States of America

Albert M Zwiener