University of Pennsylvania

University of Florida Research Foundation Inc

Cornell University

The Children's Hospital of Philadelphia

Albert M Maguire

Jean Bennett

William W Hauswirth

Gustavo D Aguirre

Gregory M Acland

Samuel Jacobson

Katherine A High

Gregory Podsakoff

Daniel Chung

Jennifer Wellman

Sarah McCague

A test of visual function and/or functional vision may be performed at varying luminance levels. A first course may be selected for a subject. A given course may comprise a layout having a beginning point, at least one turn, at least one obstacle, and an ending point. The first course may be illuminated with a first luminance level based on an estimated lower light sensitivity cutoff. The subject may be prompted to perform a first run of the test. The test may comprise, from the beginning point to the ending point, navigating the layout of the first course by walking around the at least one turn and avoiding the at least one obstacle. A determination may be made as to whether the subject successfully completed the first course based on one or both of speed or accuracy.

Apparatus and methods for testing visual function and functional vision at varying luminance levels

A method for treating an ocular disorder characterized by the defect or absence of a normal gene in the ocular cells of a human or animal subject involves administering to the subject by subretinal injection an effective amount of a recombinant adeno-associated virus carrying a nucleic acid sequence encoding the normal gene under the control of a promoter sequence which expresses the product of the gene in the ocular cells. The ocular cells are preferably retinal pigment epithelial (RPE) cells, and the gene is preferably an RPE-specific gene, e.g., RPE65. The promoter is one that can express the gene product in the RPE cells. Compositions for subretinal administration are useful in this method.

Method of treating or retarding the development of blindness

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Bryn Mawr, PA, United States of America

Albert M Maguire