Sandoz Gmbh

Albert Leutwiler

Dieter Sorg

[2-Halo-10-oxy-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene]acetic acids, for example of formula I ##STR1## wherein R.sub.1 is H or C.sub.1-4 alkyl and R.sub.2 is halogen, their physiologically-hydrolysable and -acceptable esters, and salts thereof. Such compounds, esters and salts possess valuable pharmaceutical, in particular anti-inflammatory, antipyretic and analgesic, properties.

4H-benzo[4,5]cyclohepta[1,2-b]thiophene derivatives

##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 4 carbon atoms, hydroxyalkyl with a maximum of 4 carbon atoms, the hydroxy group of which may be acylated by an alkanoyl group of 2 to 18 carbon atoms, alkoxyalkyl with a maximum of 6 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, cycloalkylalkyl of 4 to 7 carbon atoms, or a group of formula II, ##STR2## wherein R.sub.6 is hydrogen, halogen, or alkyl or alkoxy of 1 to 4 carbon atoms, and either

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Hinterkappelen, Switzerland

Albert Leutwiler