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Sanford-Burnham Medical Research Institute

Burnham Institute for Medical Research

Vala Sciences, Inc.

Albert L Kellner

Jeffrey H Price

Derek Fuller

Lam Khanh Nguyen

Martin Weinigel

Behrad Azimi

Miguel Bravo-Zanoquera

Multifunction autofocus for automated microscopy includes automatic coarse focusing of an automated microscope by reflective positioning, followed by automatic image-based autofocusing of the automated microscope performed in reference to a coarse focus position. In some aspects, the image-based autofocusing utilizes astigmatism in microscope optics for multi-planar image acquisition along a Z axis direction of a microscope. In some other aspects, the image-based autofocusing utilizes astigmatism in microscope optics in combination with chromatic aberration for multi-planar image acquisition along the Z axis direction.

Multifunction autofocus system and method for automated microscopy

In an automated scanning cytometry system, chromatic aberration is used for multiplanar image acquisition.

Automated scanning cytometry using chromatic aberration for multiplanar image acquisition

Volume imaging is supported in an optical apparatus that simultaneously acquires multiple images from multiple focal planes in an image object. A plurality of image detectors is arranged with respect to an objective lense. A plurality of reflective devices are disposed between the objective lense and the plurality of detectors to divide the light travelling through the objective lense to the detectors into channels such that each channel is registered with a respective detector.

Multiparallel three dimensional optical microscopy system

Growing community of inventors

San Diego, CA, United States of America

Albert L Kellner