Boston Scientific Scimed, Inc.

Perfusion Technology, LLC

Albert Kyle

Ulrich R Herken

Paul A Magnin

Martin Mason

Apparatus for encephalic insonication, comprising a transducer array configured to safely insonicate a field in a human body of a size comparable to the spatial extent of the array itself. The array comprises a plurality of acoustic transducers arranged in a polygonal configuration and energized in subsets at frequencies between 200 and 400 kHz. A relatively uniform insonication of a field comparable in size to that of significant anatomical regions of the brain is obtained by driving the transducers in each subset in opposed phase relationship during at least part of the interval during which they are active. A pulsed driving scheme enables minimization of heating effects while providing significant therapeutic treatment. The apparatus is useful both with and without additional lytic agents.

Encephalic insonication

A method and device selectively and reversibly disrupts the blood-brain barrier (BBB) in a selected volume of the brain without the need for exogenous agents. The method and device employ low intensity directed ultrasound (LODUS) that is safe, reduces the danger of cavitation and thermal tissue damage, and is able to expose small or large regions of the brain to achieve a desired therapeutic or prophylactic effect.

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Andover, MA, United States of America

Albert Kyle