Roche Diagnostics Operations, Inc.

Boston Probes, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Albert Geiger

Ane-Ullerup Lester

Rupert Herrmann

Uwe Kobold

Peter Sluka

Kurt Weindel

Alfons Nichtl

Michael Riedling

Hans-Ulrich Moritz

Hans Hornauer

J&ouml;rg Kleiber

Daniel Intelmann

Michael Vogeser

Jörg Kleiber

Ruediger Laubender

Kirill Tarasov

Henrik &Oslash;rum

Henrik Ørum

Julian Michely

Gernot Frackmann

A method for monitoring an analyzer including a liquid chromatography device (LC) having at least two liquid chromatography (LC) streams, the method including continuously monitoring one or more parameters in measurement data of samples in each of the at least two LC streams, the one or more parameters being independent of an analyte concentration of the respective sample, determining if the one or more monitored parameters show an expected behavior and triggering a response upon detection that the one or more monitored parameters deviate from the expected behavior.

Techniques for monitoring an analyzer including multiple liquid chromatography streams

This invention relates to magnetic particles having a glass surface which are substantially spherical. This invention also relates to methods for making them, as well as to suspensions thereof and their uses for the purification of DNA or RNA in particular in automated processes.

Magnetic glass particles, method for their preparation and uses thereof

The present invention provides a novel procedure of preparing samples for analysis by way of mass spectrometry, preferably LC-MS/MS. Accordingly, functionalized magnetic particles with a hydrophobic surface were used for extracting low molecular weight compounds from complex liquid biological samples such as plasma, serum, whole blood or hemolyzed blood. The method of the invention includes (a) contacting the sample with an amount of functionalized magnetic particles with a hydrophobic surface, (b) incubating the sample and the particles, thereby adsorbing the compound to the hydrophobic surface, (c) separating the particles by applying a magnetic field and removing the liquid, (d) optionally washing the particles, (e) eluting the compound from the particles.

Preparation of samples for LC-MS/MS using magnetic particles

The present invention relates to a method of producing a fluorescent polypeptide complex characterized in that an isolated fluorescent polypeptide is inter-molecularly cross-linked with itself or one or more other polypeptides and wherein said complex is of 40 nm to 500 nm in size, it also relates to a complex obtainable by such method, to conjugates comprising such a fluorescent polypeptide complex and to the use of such complex or conjugate.

Fluorescent polypeptide complex

A method for the detection of point mutation and polymorphisms in nucleic acids or for sequencing of unknown nucleic acids by a simple procedure using arrays uses nucleic acid analoges as sequence discriminators. This procedure simplifies the working mode in complex problematic cases.

Solid carriers with peptide nucleic acid probes and methods for regeneration

Sequence specific detection of nucleic acids using a solid carrier bound with nucleic acid analog probes

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Penzberg, Germany

Albert Geiger