Burroughs Wellcome Co.

Other

Albert G Caldwell

Norman Whittaker

Frederick C Copp

David Collard

Compounds of formula (I) ##STR1## inhibit both the cyclo-oxygenase and lipoxygenase pathways of arachidonic acid oxygenation and are useful in medicine as, e.g., anti-inflammatory and anti-asthmatic agents. The compounds may be administered as the raw chemical or in association with a carrier as a pharmaceutical formulation. The compounds may be prepared by methods analogous to those known in the art, e.g., by the method of Duffin and Kendall in J. Chem. Soc. (1954), 408-415, or by other methods.

Use of 3-(arylmethyleneamino)-1-aryl-2-pyrazolines in the prophylaxis

Heterocyclic compounds of formula (I) and acid addition salts thereof inhibit arachidonic acid oxygenation and are useful in medicine, for example as anti-inflammatory agents. ##STR1## The compounds of formula (I) may be prepared by any method analogous to those known in the art, for example by the method of G. F. Duffin and J. D. Kendall in J. Chem. Soc. (1954), 408-415. When used in medicine, the compounds of formula (I) may be administered as the compound alone or as a pharmaceutical formulation together with a pharmaceutically acceptable carrier.

3-Amino-1-phenyl-2-pyrazolines

Hydantoins of formula (I) ##STR1## have biological properties related to those of naturally occurring prostaglandins and may be used in medicine, for example in the treatment of thrombosis.

Hydantoin derivatives and pharmaceutical use

Compounds of formula (I) ##STR1## inhibit both the cyclo-oxygenase and lipoxygenase pathways of arachidonic acid oxygenation and are useful in medicine as, e.g., anti-inflammatory and anti-asthmatic agents. The compounds may be administered as the raw chemical or in association with a carrier as a pharmaceutical formulation. The compounds may be prepared by methods analogous to those known in the art, e.g. by the method of Duffin and Kendall in J. Chem. Soc. (1954), 408-415, or by other methods.

Antiinflammatory pyrazole thioureas

Hydantoin derivatives, pharmaceutical compounds and methods of use

1,3,6-Trisubstituted piperazine-2,5-diones having biological properties related to those of the natural prostaglandins, their synthesis, compositions containing them, and their use in medicine.

Nitrogen heterocycles

Hydantoins of formula (I) ##STR1## ps have biological properties related to those of naturally occurring prostaglandins and may be used in medicine, for example in the treatment of thrombosis.

Hydantoins and N-alkylhydantoins of formula (I) ##STR1## have biological properties related to those of naturally occurring prostaglandins and maybe used in medicine, for example in the treatment of thrombosis.

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West Wickham, United Kingdom

Albert G Caldwell