Nanogen Recognomics Gmbh

Sanofi

Albert Eschenmoser

Norbert Windhab

Stefan Scherer

Christian Miculka

Gerhard Quinkert

Sebastian Volker Wendeborn

Stefan Pitsch

The invention relates to conjugates including at least one linker, a biomolecule coupled to the linker, and cyclohexane derivatives of the following formula: and oligomers thereof.

Supramolecular pairing system, its preparation and use

The invention relates to a compound of formula (I), wherein R is NR R , OR or SR with R and R being H or C H independently of each other and being the same or different, n being a whole number from 1 to 12; R is equal to C H &mdash;C(X)&mdash;Y with X being &boxH;O, &boxH;S or &boxH;N, Y being equal to OR , NR R or SR , R and R having the same meaning given above, and m being a whole number from 1 to 4; or R is equal to C H &mdash;Z&mdash;Y&prime; with Z being a sulfonyl, phosphonyl, ether or amine group, Y&prime; being equal to H, C H , OR , NR R or SR then Z is sulphonyl or phosphonyl group, n, R and R having the meaning given above, and Y&prime; being equal to C H when Z is an ether or an amine group; A, B, and D are the same or different and mean CR R , O, NR ou S independently of each other with R , R and R being H or C H , independently of each other, n having the meaning given above; and C is equal to CR or N with R having the meaning of R independently, A&mdash;B, B&mdash;C or C&mdash;D not being two identical heteroatoms; and nucleobase means thymine, uracile, adenine, cytosine, guanine, isocytosine, isoguanine, xanthine or hypoxanthine. The invention also relates to a method for producing these derivatives and to their use in pairing and/or testing systems.

Processes for the preparation of 3&prime;,4&prime;-cyclic acetals of pentopyranosylnucleosides, in which the pentopyranosyl nucleoside is reacted with an aldehyde, ketone, acetal, or ketal under reduced pressure of less than about 500 mbar.

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Küsnacht, Switzerland

Albert Eschenmoser