Greatbatch Ltd.

The Johns Hopkins University

Surgi-vision Inc.

Toshiba Medical Systems Corporation

Other

Mri Interventions, Inc.

Albert Clark Lardo

Henry R Halperin

Robert A Stevenson

Warren S Dabney

Robert Shawn Johnson

Holly Noelle Moschiano

Ergin Atalar

Kishore Kumar Kondabatni

Scott Brainard

Ronald David Berger

Christopher Michael Williams

Elliot R McVeigh

Christine A Frysz

Buehl E Truex

Daniel Robert Kaiser

Hugh Calkins

Joao Lima

Paul Arthur Bottomley

Elliott R McVeigh

Barry C Muffoletto

Takashi Ichihara

Parag V Karmarkar

Joao A C Lima

Scott W Kelley

Richard T George

Jung Hee Seo

Rajat Mittal

Richard L Brendel

Jeff Fleigle

Christine McNamara

Xiaoming Yang

Eduardo Marban

Neal N Nesselbeck

Toshihiro Rifu

Joseph E Spaulding

Robert Charles Susil

Arkadiy Tsitlik

Amir Pourmorteza

Karl H Schuleri

Holly Noelle Mosciano

Steve Tulley

Gwyneth Susil

Nathaniel M Fried

Elias Zerhouni

Hugh Caikins

Elias Zerhouin

Robert Susil

Fady Dawoud

Elliott R Mcveigh

Christine Enger Mcnamara

Robert C Susil

Elliot Mcveigh

Elliot R Mcveigh

The present invention is directed to a method for combining assessment of different factors of dyssynchrony into a comprehensive, non-invasive toolbox for treating patients with a CRT therapy device. The toolbox provides high spatial resolution, enabling assessment of regional function, as well as enabling derivation of global metrics to improve patient response and selection for CRT therapy. The method allows for quantitative assessment and estimation of mechanical contraction patterns, tissue viability, and venous anatomy from CT scans combined with electrical activation patterns from Body Surface Potential Mapping (BSPM). This multi-modal method is therefore capable of integrating electrical, mechanical, and structural information about cardiac structure and function in order to guide lead placement of CRT therapy devices. The method generates regional electro-mechanical properties overlaid with cardiac venous distribution and scar tissue. The fusion algorithm for combining all of the data suggests cardiac segments and routes for implantation of epicardial pacing leads.

Imaging toolbox for guiding cardiac resynchronization therapy implantation from patient-specific imaging and body surface potential mapping data

An embodiment in accordance with the present invention provides a method for non-invasively determining the functional severity of coronary artery stenosis. The method includes gathering patient-specific data related to concentration of a contrast agent within a coronary artery of a patient using a coronary computed tomography angiography scan (CCTA). The patient-specific data is used to calculate a patient-specific transluminal attenuation gradient for the coronary artery of the patient. The patient specific transluminal attenuation gradient is used to determine an estimate of a coronary flow velocity, pressure gradient, loss coefficient, coronary flow reserve, and/or fractional flow reserve for the patient. Coronary flow velocity, pressure gradient, loss coefficient, coronary flow reserve, and fractional flow reserve can then be used to estimate the functional severity of coronary artery stenosis.

Method for estimating flow rates, pressure gradients, coronary flow reserve, and fractional flow reserve from patient specific computed tomography angiogram-based contrast distribution data

A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures includes an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and diagnostic electrodes for receiving electrical potentials. The combined electrophysiology and imaging antenna catheter is used in combination with a magnetic resonance imaging scanner to guide and provide visualization during electrophysiologic diagnostic or therapeutic procedures, such as ablation of cardiac arrhythmias. The combined electrophysiology and imaging antenna catheter may further include an ablation tip, and be used as an intracardiac device to deliver energy to selected areas of tissue and visualize the resulting ablation lesions.

System and method for magnetic-resonance-guided electrophysiologic and ablation procedures

An embodiment in accordance with the present invention provides a method for non-invasively determining the functional severity of arterial stenosis in a selected portion of an arterial network. The method includes gathering patient-specific data related to concentration of a contrast agent within an arterial network using a coronary computed tomography angiography scan (CCTA). The data can be gathered under rest or stress conditions. Estimation of a loss coefficient (K) can be used to eliminate the need for data gathered under stress. The data is used to calculate a transluminal attenuation gradient (TAG). The data may be corrected for imaging artifacts at any stage of the analysis. TAFE is used to determine an estimate of flow velocity. Once velocity is determined, pressure gradient, coronary flow reserve, and/or fractional flow reserve can be determined through a variety of methods. These estimates can be used to estimate functional severity of stenosis.

Method for estimating flow rates and pressure gradients in arterial networks from patient specific computed tomography angiogram-based contrast distribution data

Herein is disclosed a probe, including a first electrode disposed at least partially on the probe surface, a second electrode disposed at least partially on the probe surface, a first conductor electrically coupled to the first electrode, a second conductor electrically coupled to the second electrode, and a reactive element electrically coupling the first conductor and the second conductor.

MRI compatible medical leads

A shielded component or network for an active medical device (AMD) implantable lead includes an implantable lead having a length extending from a proximal end to a distal end, all external of an AMD housing, a passive component or network disposed somewhere along the length of the implantable lead, the passive component or network including at least one inductive component having a first inductive value, and an electromagnetic shield substantially surrounding the inductive component or the passive network. The first inductive value of the inductive component is adjusted to account for a shift in its inductance to a second inductive value when shielded.

Electromagnetic shield for a passive electronic component in an active medical device implantable lead

An energy management system facilitates the transfer of high frequency energy coupled into an implanted lead at a selected RF frequency or frequency band, to an energy dissipating surface. This is accomplished by conductively coupling the implanted lead to the energy dissipating surface through an energy diversion circuit including one or more passive electronic network components whose impedance characteristics are at least partially tuned to the implanted lead's impedance characteristics.

Tuned energy balanced system for minimizing heating and/or to provide EMI protection of implanted leads in a high power electromagnetic field environment

A shielded component or network for an active medical device (AMD) implantable lead includes (1) an implantable lead having a length extending from a proximal end to a distal end, all external of an AMD housing, (2) a passive component or network disposed somewhere along the length of the implantable lead, the passive component or network including at least one inductive component having a first inductive value, and (3) an electromagnetic shield substantially surrounding the inductive component or the passive network. The first inductive value of the inductive component is adjusted to a account for a shift in its inductance to a second inductive value when shielded.

Implantable lead having a shielded bandstop filter comprising a self-resonant inductor for an active medical device

A medical lead system includes at least one bandstop filter for attenuating current flow through the lead across a range of frequencies. The bandstop filter has an overall circuit Q wherein the resultant 3 dB bandwidth is at least 10 kHz. The values of capacitance and inductance of the bandstop filter are selected such that the bandstop filter is resonant at a selected center frequency or range of frequencies. Preferably, the bandstop filter has an overall circuit Q wherein the resultant 10 dB bandwidth is at least 10 kHz. Such bandstop filters are backwards compatible with known implantable deployment systems and extraction systems.

Implantable lead bandstop filter employing an inductive coil with parasitic capacitance to enhance MRI compatibility of active medical devices

An energy management system that facilitates the transfer of high frequency energy induced on an implanted lead or a leadwire includes an energy dissipating surface associated with the implanted lead or the leadwire and at least one non-linear circuit element switch for diverting energy in the implanted lead or the leadwire to the energy dissipating surface. In alternate configurations, the switch may be disposed so that it electrically opens the implanted lead or the leadwire when diverting energy to the energy dissipating surface. The non-linear circuit element switch is typically a PIN diode.

Circuits for minimizing heating of an implanted lead and/or providing EMI protection in a high power electromagnetic field environment

A lead extending exteriorly from an active implantable medical device (AIMD) is at least partially ensheathed within an electromagnetic interference (EMI) shield. The AIMD has a conductive equipotential surface to which the EMI shield may be conductively coupled. An impeding circuit may be provided for raising the high frequency impedance of the lead. An energy diversion circuit may also be provided for conductively coupling the lead to the EMI shield.

Active implantable medical system having EMI shielded lead

An energy management system that facilitates the transfer of high frequency energy induced on an implanted lead or a leadwire includes an energy dissipating surface associated with the implanted lead or the leadwire, a diversion or diverter circuit associated with the energy dissipating surface, and at least one non-linear circuit element switch for diverting energy in the implanted lead or the leadwire through the diversion circuit to the energy dissipating surface. In alternate configurations, the switch may be disposed between the implanted lead or the leadwire and the diversion circuit, or disposed so that it electrically opens the implanted lead or the leadwire when diverting energy through the diversion circuit to the energy dissipating surface. The non-linear circuit element switch is typically a PIN diode. The diversion circuit may be either a high pass filter or a low pass filter.

Switched diverter circuits for minimizing heating of an implanted lead and/or providing EMI protection in a high power electromagnetic field environment

Growing community of inventors

Baldwin, MD, United States of America

Albert Clark Lardo