American Home Products Corporation

Albert A Mascitti

Theodore S Sulkowski

James L Bergey

Paul J Silver

Reinhold H Bender

4-(2,3-dichloro-6-fluorophenyl)-1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-1,7-na phthyridine-3-carboxylic acid 2-(2,3-dichlorophenoxy)ethyl ester and pharmaceutically acceptable salts thereof are useful antihypertensive agents.

4-(2,3-dichloro-6-fluorophenyl)-1,4,5,6,7,8-hexahyd

1,4,5,6,7,8-Hexahydro-2-alkyl-4-aryl-5-oxo-1,7-naphthyridine-3-carboxylic acid aromatic esters and pharmaceutically acceptable acid addition salts thereof are useful antihypertensive agents.

1,4,5,6,7,8-Hexahydro-2-alkyl-4-aryl-5-oxo-1,7-naphthyridine-3-carboxyl

7-(Substituted)-1,4,5,6,7,8-hexahydro-2-alkyl-4-aryl-5-oxo-1,7-naphthyridin e-3-carboxylic acid esters and pharmaceutically acceptable acid addition salts thereof are useful antihypertensive agents.

Aralkyl or aryloxyalkyl 1,7-naphthyridine-3-carboxylic acid esters

Compounds of the formula: ##STR1## wherein: Y is 2,6-dimethylphenyl, 2,5-dimethylphenyl, 5-bromo-2-methylphenyl, or 5-chloro-2-methylphenyl; and

N-3-Propenylaminopropyl-N'-phenylureas

1,4,5,6,7,8-Hexahydro-2-alkyl-4-pentafluorophenyl-5-oxo-1,7-naphthyridine-3 -carboxylic acid esters and pharmaceutically acceptable salts thereof are useful antihypertensive agents.

Antihypertensive agents

Compounds of the formula: ##STR1## wherein: Y is 2,6-dimethylphenyl, 2,5-dimethylphenyl, [5-bromo-2-methylphenyl], or 5-chloro-2-methylphenyl; and

Anti-arrhythmic N-[3-alkylaminopropyl]-N'-phenylureas

1,4,5,6,7,8-hexahydro-2-alkyl-4-aryl-5-oxo-1,7-naphthyridine-3-carboxylic acid esters and pharmaceutically acceptable salts thereof are useful antihypertensive agents.

Method of suppressing cardiac arrhythmias compounds of the formula: ##STR1## wherein: Y is 2,6-dimethylphenyl, 2,5-dimethylphenyl, 5-bromo-2-methylphenyl, or 5-chloro-2-methylphenyl; and

Method of suppressing cardiac arrhythmias

Compounds of the formula: ##STR1## wherein: Y is 2,6-dimethylphenyl, 2,5-dimethylphenyl, 3,5-dimethylphenyl, 2-chloro-6-methylphenyl, or 5-chloro-2-methylphenyl; and

N-[3-(lower)alkylaminopropyl]-N'-(disubstituted)phenylureas

(Hexahydrobenzimidazol-2-yl)benzophenones are prepared by reaction of the .psi.-acid chloride of an o-aroyl benzoic acid with an N-monotosyl-1,2-diaminocyclohexane, and heating the resulting benzoyl benzamide product with sulfuric acid. The intermediate benzoyl benzamides are also claimed as are the benzophenones. The compounds are useful in hyperglycemia therapy.

(Hexahydrobenzimidazol-2-yl)benzophenones and derivatives

2-(N-alkyl-2-imidazolin-2-yl)-benzophenones are prepared by reaction of the .psi.-acid chloride of an o-aroyl benzoic acid with an N.sup.1 -alkyl-N.sup.2 -tosyl diamine and heating the resulting benzoyl benzamide product with sulfuric acid. The compounds demonstrate hypoglycemic antireserpine, antiulcerogenic or antiarrhythmic activity.

Growing community of inventors

Norristown, PA, United States of America

Albert A Mascitti