Smith Kline & French Laboratories Limited

Sk&f Laboratories Ltd.

Albert A Jaxa-Chamiec

Deirdre M Hickey

David G Cooper

Virendra P Shah

David Alston

Polymethacrylate polymers, pharmaceutical compositions containing them and their use in medicine as cholesterol lowering agents. A particular polymer of the invention is 11-N,N,N-trimethylammonioundecyl methacrylate chloride copolymer.

Compounds

##STR1## Substituted 4,5-diaryl-2-imidazolones of structure (I), in which each group AR is the same or different and is optionally substituted phenyl or optionally substituted heteroaryl; R.sup.1 is hydrogen, alkyl, optionally substituted phenyl or optionally substituted heteroaryl; n is 4 to 12; and X is 5-tetrazolyl, SO.sub.3 H, P(O)(OR).sub.2, P(O)(OH).sub.2 or P(O)(R)(OR) in which R is hydrogen acceptable salt thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, inter alia, in the treatment of cardiovascular disorders.

Substituted 2-imidazolone derivatives, their preparation and

Polystyrene polymers bearing a quaternary ammonium group are disclosed. They are useful in the treatment of hypercholesterolaemia and the prevention of atherosclerosis. A compound of the invention is 6-(N,N-dimethyl-N-octylammonio)hexanoylated polystyrene chloride.

Polystyrene anion exchange polymers

Polystyrene polymers having a quaternised ammonium group and their use in a method of treatment of hypercholesterolaemia. A particular compound of the invention is (N,N-dimethyl-N-dodecyl-ammoniomethylstyrene-ethyl methacrylate-divinylbenzene co-polymer, chloride salt.

Polystyrene anion exchange polymer pharmaceutical composition

Polymers bearing a quaternary ammonium group are disclosed as being useful in lowering serum cholesterol levels in man. A compound of the invention is N,N-dimethyl-N-(2-(N,N-dimethylcarbamoyl)ethyl)-ammoniomethyl-substitut ed polystyrene, chloride salt.

Polymers bearing a quaternary ammonium group are disclosed as being useful in lowering serum cholesterol levels in man. A compound of the invention is N-(2-N,N-dimethylamino)ethyl)-N,N-dimethylammoniomethyl-substituted polystyrene, chloride salt.

Polystyrene polymers having a quaternized ammonium group and their use in a method of treatment of hypercholesterolaemia. A particular compound of the invention is N,N-dimethyl-N-dodecylammoniomethyl-substituted polystyrene.

Growing community of inventors

Rickmansworth, United Kingdom

Albert A Jaxa-Chamiec