The University of Melbourne

Alastair George Stewart

Christine Keenan

Trudi Harris

Spencer John Williams

Maree Patricia Collis

Alan Duncan Robertson

Thomasz Bilski

Martin Banwell

David James McAllister

Brenda Leung

Xumei Gao

Anu Augustine

Zalihe Hakki

Jacki Kitching

The present invention relates to new compounds that are useful in the prevention or treatment of respiratory diseases, such as asthma, acute and chronic inflammatory conditions, and fibrotic diseases or conditions in which fibrosis contributes to the pathology of the condition. The invention also relates to the preparation of the compounds, and to compositions including the compounds. The present invention also relates to the use of the compounds, as well as compositions including the compounds, in treating or preventing respiratory diseases, acute and chronic inflammatory conditions, and fibrotic diseases or conditions in which fibrosis contributes to the pathology of the condition.

Compounds for the treatment of respiratory diseases

The invention provides a rotor for a peristaltic pump, the rotor comprising a body for rotation about an axis, the body having a first side and a second side, the body supporting a plurality of spaced first rollers extending from the body on the first side, the first rollers positioned at a first common radius from the axis, the body further supporting a plurality of spaced second rollers extending from the body on the second side, the second rollers positioned at a second common radius from the axis. The invention extends to a peristaltic pumping unit comprising such a rotor assembled with a first stator and a second stator, the first stator having one or more compressible fluid channels arranged to be compressed by said first rollers and the second stator having one or more compressible fluid channels arranged to be compressed by said second rollers. The invention also concerns a stator for a peristaltic pump, having a body with a planar surface and two or more fluid channels, each fluid channel having a compressible arcuate portion on or in the planar surface of the stator, the arcuate portions arranged to be compressed by a plurality of rollers mounted on a rotor, the arcuate portions each connecting to further portions of the fluid channel extending in a direction away from the planar surface such that the fluid channels take a three dimensional path within the body of the stator.

Peristaltic pump rotor, stator and roller arrangement

The present invention relates to compositions, methods and kits for the treatment of respiratory disease. In particular, the compositions, methods and kits are particularly useful, but not limited to, the treatment or prevention of exacerbations of asthma and chronic obstructive pulmonary disease. The present invention provides a method of treating or preventing a respiratory disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of casein kinase 1, thereby treating or preventing a respiratory disease in a subject. The present invention also provides a method of treating or preventing a respiratory disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of ALK5, thereby treating or preventing a respiratory disease in a subject, wherein the inhibitor is administered directly to the airway and/or lungs. The present invention also provides a method of treating or preventing a condition of the airway or lung involving fibrosis in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of casein kinase 1 or an inhibitor of ALK5, thereby treating or preventing a condition of the airway or lung involving fibrosis in a subject.

Treatment of respiratory diseases

The present invention relates to non-steroidal compounds useful in the treatment of inflammatory conditions and pharmaceutical compositions comprising them. A representative example of these compounds is 

Non-steroidal compounds

A conjugated prodrug of an estradiol compound conjugated to a biological activity modifying agent.

Estradiol conjugates and uses thereof

Growing community of inventors

North Balwyn, Australia

Alastair George Stewart