Gilead Sciences, Inc.

Amgen Inc.

Amgen Sf, LLC

Alan X Huang

Richard L Mackman

James Ming Chen

William John Watkins

Choung U Kim

Hyung-Jung Pyun

Aesop Cho

Jennifer R Zhang

Thorsten A Kirschberg

Adrian S Ray

David A Oare

Lee Shun Chong

Sundaramoorthi Swaminathan

Maria Fardis

Carina E Cannizzaro

Constantine G Boojamra

Xiaowu Chen

Christopher P Lee

David Y Markevitch

Vidya K Prasad

Julio Cesar Medina

William A Lee

Haolun Jin

Ralph F Hirschmann

Liusheng Zhu

Jiwen Liu

Peter H Nelson

Kuei-Ying Lin

Michael G Johnson

Lijun Zhang

An-Rong Li

Rosemarie Sherlock

Manoj C Desai

Oliver L Saunders

Feng Xu

Jason K Perry

Steven H Krawczyk

Andrew P Marcus

Xuemei Wang

Rosemarie O'Shea

Jonathan B Houze

Jay P Parrish

David Sperandio

Craig S Gibbs

Qingge Xu

Tassie Collins

Hossen Mahmud

Sundaramoorthi Swaninathan

The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Antiviral phosphonate analogs

The invention provides unsaturated phosphonates of Formula I or a tautomer or pharmaceutically acceptable salt thereof, as described herein, as well as pharmaceutical compositions comprising the compounds, and therapeutic methods comprising administering the compounds. The compounds have anti-viral properties and are useful for treating viral infections (e.g. HCV) in animals (e.g. humans). 

Nucleoside analogs for antiviral treatment

A compound of Formula I, Formula II, Formula III, or Formula IV: or a pharmaceutically acceptable salt, solvate, and/or ester thereof, therapeutic compositions containing such compounds, and therapeutic methods that include the administration of such compounds.

Phosphonate inhibitors of HCV

The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents.

Therapeutic phosphonate compounds

The invention is related to phosphonate substituted compounds having immuno-modulatory activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Phosphonate compounds having immuno-modulatory activity

The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Anti-cancer phosphonate analogs

Compounds, compositions and methods are provided that are useful in the treatment of chemokine receptor-mediated conditions and diseases. In particular, the invention provides compounds which modulate CCR4 function or a CCR4-mediated response. The subject compounds and compositions are useful for the treatment or prevention of inflammatory conditions and diseases.

CCR4 antagonists

Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes.

CXCR3 antagonists

Compounds are provided that have the formula: where X, A, R, R, R, R, R, R, L and Q are as described herein. These compounds are useful, for example, as modulators of a chemokine receptor and for treatment of inflammatory and immunoregulatory disorders and diseases. Pharmaceutical compositions and methods of using these compounds for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes, are also provided.

Substituted Quinazolin-4(3H)-one compounds, compositions, and methods for their use

Substituted pyrido[2,3-d]pyrimidines and methods for their use

The present invention provides compounds, compositions and methods for the inhibition or treatment of conditions or disorders modulated by the STAT transcription factors, particularly STAT4 and STAT6. Additionally, the compounds are useful for the diagnosis of conditions dependent on STAT signaling.

STAT modulators

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San Mateo, CA, United States of America

Alan X Huang