Hawaii Biotech, Inc.

Panthera Biopharma LLC

Exelixis, Inc.

Other

Exelixis Patent Company LLC

X-ceptor Therapeutics, Inc.

Alan Thomas Johnson

Guan-Sheng Jiao

Raju Mohan

Seong Jin Kim

Sean O'Malley

Edwin J Schweiger

Christopher D Bayne

Henry Lee Jackson

Michael Charles Nyman

Haixia Wang

William C Stevens, Jr

Yinong Xie

Shao-Po Lu

Seongjin Kim

Ronald Griffith

Satoru Kaneko

Shao Po Lu

Kozo Oda

Compounds of formula I are provided: wherein X is NH, or CH, Y is a single bond, or &#x2014;CHR&#x2014;, Ris H, C-Calkyl, or C-Chydroxyalkyl, Rand R' are each independently H, C-Calkyl, or C-Chydroxyalkyl, each Ris independently H, halo, &#x2014;CF, C-Calkyl, or C-Calkoxy, Cperhaloalkyl, each Ris independently H, halo, or C-Calkyl, Ris C-Calkoxy, r is integer from 0 to 3; and p is integer from 0 to 3.

Pyridin-2-yl alkylamino substituted hydroxamic acid and uses thereof

Compounds of Formula I are provided: Ris &#x2014;OR, m is an integer from 0 to 5, n is an integer from 0 to 2, each Ris independently selected from hydrogen, halogen, and alkyl, Ris selected from hydrogen, alkyl, cycloalkyl, aryl, hydroxyalkyl, alkoxyalkyl, aryloxyalkyl, aralkyloxyalkyl, aralkyl, alkylaminoalkyl, dialkylaminoalkyl, aralkylaminoalkyl, and heterocycloalkyl, Ris an alkyl, each Ris independently hydrogen or alkyl, and each of R, R, R, and Ris independently optionally substituted. Compounds of Formula I are included in pharmaceutical compositions for the treatment of a subject exposed to atoxin.

Hydroxamic acids comprising pyrazole moiety and uses thereof

Compounds of formula I are provided: Ris an alkoxy or O(CH)X, p is an integer from 2 to 3 and X is OH, NH, or COH, m is an integer from 0 to 5, n is an integer from 0 to 5, each Ris independently selected from hydrogen, alkenyl, hydroxyalkyl, alkoxymethyl, heterocyclyl, hetereocyclylmethyl, amino, amido, hydroxamido, any of which may be optionally substituted with one or more of acyl, alkyl, alkoxy, hydroxyalkyl, or halogen, each Ris independently selected from hydrogen, halogen, alkyl, alkenyl, carboxy, hydroxymethyl, amido, and at least one of Rand Ris not hydrogen.

Hydroxamic acids and uses thereof

Compounds having the formula wherein the symbols have the meaning described in the specification are hydroxamic acid derivatives of aniline and capable of inhibiting the lethal effects of infection by anthrax bacteria and are useful in the treatment of poisoning by anthrax.

Hydroxamic acid derivatives of aniline useful as therapeutic agents for treating anthrax poisoning

Compounds having the formula wherein the symbols have the meaning described in the specification are hydroxamic acid derivatives of 4-phenyl-4-hydroxy-butyric acid and capable of inhibiting the lethal effects of infection by anthrax bacteria and are useful in the treatment of poisoning by anthrax.

Hydroxamic acid derivatives of 4-phenyl 4-hydroxy, 4-phenyl 4-alkoxy and 4-phenyl 4-arylalkoxy butyric acid useful as therapeutic agents for treating anthrax poisoning

Compounds of the invention, such as compounds of formula (I): 

Modulators of LXR

Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of nuclear receptors, including liver X receptor (LXR) and orphan nuclear receptors. In certain embodiments, the compounds are N-substituted pyridones.

Compounds having the formula wherein the symbols have the meaning described in the specification are hydroxamic acid derivatives of phenoxy-acetic acids and analogs capable of inhibiting the lethal effects of infection by anthrax bacteria and are useful in the treatment of poisoning by anthrax.

Hydroxamic acid derivatives of phenoxy-acetic acids and analogs useful as therapeutic agents for treating anthrax poisoning

Compounds having the formula wherein the symbols have the meaning described in the specification are hydroxamic acid derivatives of 3-phenyl-propionic acid and capable of inhibiting the lethal effects of infection by anthrax bacteria and are useful in the treatment of poisoning by anthrax.

Hydroxamic acid derivatives of 3-phenyl propionic acids useful as therapeutic agents for treating anthrax poisoning

Compounds of formula (I): wherein n, R, R, Rand Rare disclosed herein, are useful in treating disease-states associated with nuclear receptor activity. Pharmaceutical compositions comprising and methods of using said compounds are also disclosed herein.

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Kaneohe, HI, United States of America

Alan Thomas Johnson