Smithkline Beecham Corporation

Glaxo Group Limited

Ligand Pharmaceuticals, Inc.

Alan T Price

Juan I Luengo

Kevin J Duffy

Antony N Shaw

Julian Jenkins

William Henry Miller

Connie L Erickson-Miller

Stephen F Miller

Kenneth Wiggall

Sophie Visonneau

Lihua Zhang

Daniel F Eppley

Nannan Liu

2H-chromen-2-one derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.

Antibacterial agents

Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.

Thrombopoietin mimetics

Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected substituted thiosemicarbazone derivative.

Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected substituted naphthimidazole derivative.

Naphthimidazole derivatives and their use as thrombopoietin mimetics

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Collegeville, PA, United States of America

Alan T Price