Allergan, Inc.

Allergan Sales, Inc.

Other

Allergen Sales, Inc.

Alan T Johnson

Roshantha A Chandraratna

Vidyasagar Pradeep Vuligonda

Richard L Beard

Min Teng

Tien T Duong

Samuel J Gillett

Jayasree Vasudevan

Yuan Lin

Dehua Huang

Liming Wang

Sunil Nagpal

Andrew M Standeven

Elliott S Klein

Tae K Song

Harold N Wong

Michael E Garst

Brian Philip Mathews

Elliot S Klein

Micah Nolte

A fun and affordable animated toy robot operates with varying degrees of autonomy and anthropomorphism. The robot may include a customized chipboard controller or computer, a power source, and may be constructed with specialized connectors, magnets, servo motors, generally less-sturdy (or pliable) thin materials, such as chipboard, card stock, cardboard, or the like, used for the body and limbs of the robot, and LEDs. The specialized connectors may be used to attach the servos to these materials. An application and the controller may be used to control the motion of the robot. Young children may be able to make the attachments to build the robot with little or without the help of adults or older children. Building and operating the robot may be fun activities for children and families, and may provide enjoyable learning activities about robotics.

Animated robots having varying degrees of autonomy and anthropomorphism

A golf putting training device with a base and a plurality of posts extending upwardly from the base is provided. The plurality of posts may be positioned on a diameter of a circle and the diameter may be generally equal to a golf hole diameter. A distance between at least two of the plurality of posts is less than the golf hole diameter and thereby provides a narrow opening for a golf ball to roll through. A pair of sleeves may be positioned on a pair of adjacent posts such that the narrow opening for the golf ball to roll through is reduced. Also, an elastic member may extend between two posts and across the narrow opening for the golf ball to roll through such that a golf ball putted towards the narrow opening is redirected when it is rolls into the elastic member.

Golf putting training devices and methods of use thereof

Disclosed herein are compounds of the formula wherein Ris independently H or alkyl of 1 to 6 carbons;

Aryl substituted 3,4-dihydroanthracene derivatives having retinoid antagonist or retinoid inverse agonist type biological activity

A method of identifying a compound which is an inhibitor of the enzyme cytochrome P450RAI is performed by selecting a compound that has retinoid activity in an art recognized assay and includes a benzoic acid, benzoic acid ester, naphthoic acid ester or heteroaryl carboxylic acid or ester moiety, with a partial structure of &#x2014;A(R)&#x2014;(CH)where n is 0 and the remaining variables are as described in the specification and claims. Thereafter, a compound having the cytochrome P450RAI inhibitory activity is identified and selected where the compound has the &#x2014;A(R)&#x2014;(CH)&#x2014;COORpartial structure wherein the variable n is 1 or 2.

Methods for identifying inhibitors of cytochrome P450RAI

Compounds of the formulawhere the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.

O- or S-substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity

Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity

Compounds having Formula 4 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.

Compounds having activity as inhibitors of cytochrome P450RAI

Compounds having Formula 4 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids

1-imidazolyl substituted tetrahydronaphthalene derivatives as inhibitors of eytochrome P450RAI

ARYL OR HETEROARYL SUBSTITUTED 3,4-DIHYDROANTHRACENE AND ARYL OR HETEROARYL SUBSTITUTED BENZO &lsqb;1,2-G&rsqb;CHROM-3-ENE, BENZO&lsqb;1,2-G&rsqb;-THIOCHROM-3-ENE AND BENZO &lsqb;1,2-G&rsqb;-1,2-DIHYDROQUINOLINE DERIVATIVES HAVING RETINOID ANTAGONIST OR RETINOID INVERSE AGONIST TYPE BIOLOGICAL ACTIVITY

Compounds having Formula 1 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.

Aryl-substituted and aryl and (3-oxo-1-propenly)-substituted benzopyran, benzothiopyran, 1,2-dihydroquinoline, and 5,6-dihydronaphthalene derivatives have retinoid negative hormone and/or antagonist-like biological activities. The invented RAR antagonists can be administered to mammals, including humans, for the purpose of preventing or diminishing action of RAR agonists on the bound receptor sites. Specifically, the RAR agonists are administered or coadministered with retinoid drugs to prevent or ameliorate toxicity or side effects caused by retinoids or vitamin A or vitamin A precursors. The retinoid negative hormones can be used to potentiate the activities of other retinoids and nuclear receptor agonists. For example, the retinoid negative hormone called AGN 193109 effectively increased the effectiveness of other retinoids and steroid hormones in in vitro transactivation assays. Additionally, transactivation assays can be used to identify compounds having negative hormone activity. These assays are based on the ability of negative hormones to down-regulate the activity of chimeric retinoid receptors engineered to possess a constitutive transcription activator domain.

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Rancho Santa Margarita, CA, United States of America

Alan T Johnson