Praxair Technology, Inc.

Union Carbide Industrial Gases Technology Corporation

Alan T Cheng

Ramon R Barrado

Jose R Calvo

Yeu-Chuan Simon Ho

Donald Leonard DeVack

Deepak Lumba

Ying Zhou

John Fredric Billingham

Thomas John Bergman, Jr

Theodore Hall Gasteyer

Robert Rex Sever

Balazs Hunek

Royce S Fishman

Nigel Grinter

Jeffrey P Kingsley

Bryan R Bielec

Mitchell Adis

Steven Donald Clark

Stephan C F Gamard

Mark Herbert Kirby

Victor Alexander Coppola

Pedro L Durao

Paolo Sergio Bon

Simon Ho

Arup Nandi

Disclosed are a system and a method for dissolving water-soluble gas such as oxygen into water, employing microporous membrane.

System and method for feeding gas into liquid

A system and method for solvent recovery in a batch fluidized bed process is provided. The disclosed embodiment of the fluidized bed system includes a fluidized bed vessel adapted to contain a batch of solvent-containing product; an influent or intake circuit adapted to supply an inert fluidizing gas to the fluidized bed vessel; an effluent circuit adapted to remove the solvent containing inert fluidizing gas from the fluidized bed vessel; a first recycle circuit coupling the effluent circuit to a solvent recovery means; a second recycle circuit directly coupling the effluent circuit to the intake circuit and a flow control valve operatively disposed to divide the effluent between the first recycle circuit and the second recycle circuit based on the operating regime of the fluidized bed process. The disclosed embodiments further include a source of liquid nitrogen coupled to the second recycle circuit to provide the make-up inert gas as well as provide enhanced cooling of the effluent based on the operating regime of the fluidized bed process.

System and method for solvent recovery in a batch fluidized bed process

A cryogenic refrigeration system for lyophilization is disclosed. The cryogenic refrigeration system includes a cryogenic heat exchanger system adapted for vaporizing a liquid cryogen and using the gaseous cryogen to cool heat transfer fluid and a heat transfer cooling circuit that cools the lyophilization chamber as well as the condenser. The disclosed heat transfer cooling circuit includes a primary recirculation loop adapted for cooling the lyophilization chamber with the heat transfer fluid, a secondary recirculation loop adapted for cooling a condenser with the heat transfer fluid, and one or more valves operatively coupling the cryogenic heat exchanger system, the primary recirculation loop, and the secondary recirculation loop.

Method for lyophilization using cryogenic refrigeration system

A method and system for controlled rate freezing and nucleation of materials is provided. The presently disclosed system and method provides the ability to rapidly cool the materials contained in vials or other containers within a cooling unit via forced convective cooling using a laminar and uniform flow of cryogen in proximity to the plurality of vials disposed within the cooling unit. The rapid cooling of the biological materials is achieved by precisely controlling and adjusting the temperature of the cryogen being introduced to the system as a function of time. The presently disclosed methods to systems also provide nucleation control via temperature quench and depressurized nucleation control.

Method and system for regulating the mixture of cryogen liquid and warm gas for a controlled rate cryogenic chiller or freezing system

A method and system for controlled rate freezing of biological materials is provided. The presently disclosed system and method provides the ability to rapidly cool the biological materials contained in vials or other containers within a cooling unit via forced convective cooling using a laminar and uniform flow of cryogen in proximity to the plurality of vials disposed within the cooling unit. The rapid cooling of the biological materials is achieved by precisely controlling and adjusting the temperature of the cryogen being introduced to the system as a function of time.

Method and system for controlled rate freezing of biological material

Method and system for nucleation control in a controlled rate freezer (CRF)

A cryogenic refrigeration system includes a cryogenic heat exchanger system adapted for vaporizing a liquid cryogen and using the gaseous cryogen to cool heat transfer fluid and a heat transfer cooling circuit that cools the lyophilization chamber as well as the condenser. The disclosed heat transfer cooling circuit includes a primary recirculation loop adapted for cooling the lyophilization chamber with the heat transfer fluid, a secondary recirculation loop adapted for cooling a condenser with the heat transfer fluid, and one or more valves operatively coupling the cryogenic heat exchanger system, the primary recirculation loop, and the secondary recirculation loop.

Cryogenic refrigeration system for lyophilization

An inhaler comprising a compressed gas, such as Heliox gas is provided. The disclosed inhaler includes a first chamber containing a compressed gas which is in communication with an equalization chamber having pressure lower than the pressure of the gas in the first chamber. The inhaler also includes a drug storage chamber which is detachably coupled to the equalization chamber and operable such that a portion of the compressed gas from the equalization chamber fluidizes and aerosolizes the drug to produce a drug cloud. The drug cloud is directed into a spacer where it can be inhaled by a user.

Portable gas operating inhaler

A method and condenser apparatus for cleaning a gas of condensable vapor employing a cryogenic liquid which is caused to boil evenly along the condenser length and wherein the gas flow through the condenser is in the downward direction in evenly divided flows countercurrently to the flow of boiled cryogen.

Cryogenic condensation system

The tendency of carbonated beverage to generate excessive foam when it is produced and bottled is reduced in a process including: (a) providing water or a mixture of water and syrup, which contains oxygen or air dissolved therein, and maintaining a pressure greater than atmospheric thereon; (b) saturating said mixture with carbon dioxide, and feeding the resultant mixture to step (c), while maintaining sufficient pressure thereon that no dissolved gas evolves therefrom; and (c) removing dissolved oxygen or air from the mixture formed in step (b) while dissolving additional carbon dioxide into said mixture and maintaining over said mixture a pressure greater than atmospheric.

Precarbonation process to reduce foaming

An apparatus for and method of delivering a liquid cryogen into a reaction vessel to cool an exothermic reaction within the vessel wherein the liquid cryogen can be supplied directly into the reaction vessel at a maximum high pressure of about 3000 psi is provided. The liquid cryogen may come directly from a high pressure liquid cryogen storage tank without any pressure regulators or control valves between the reaction vessel and the storage tank thereby reducing flashing and eliminating the need for sub-cooling the liquid cryogen.

Method of using high pressure LN2 for cooling reactors

A system for the dissolution of gas in a large body of liquid comprising an impeller positioned below the surface of the large body of liquid; a floating hood positioned over the impeller and of sufficient size to capture undissolved gas; a conduit for introducing a feed gas stream beneath the floating hood and directly into the large body of liquid; at least one segregation ring positioned under the floating hood and extending below the surface of the large body of liquid such that a first inner region between the ring and the impeller, and a second outer region between the ring and an outer diameter of the floating hood are created, and a back pressure regulator located in the floating hood adjacent to the outer diameter of the floating hood.

System for enhanced gas dissolution having a hood positioned over the

A gas driven fermentation system wherein a gas such as air is passed heterogeneously upwardly through the fermentation broth to agitate and recirculate the broth, provide oxygen for fermentation and strip off carbon dioxide, and a second gas such as oxygen is passed homogeneously upwardly through the broth proximate the heterogeneous air flow to provide supplemental oxygen for fermentation.

Gas driven fermentation system

Method and apparatus for effectively and safely using cryogenic liquid to cool a reactor vessel housing an exothermic reaction wherein the cryogenic liquid is subcooled, valved into the reactor in a downward direction, and shielded by annular coaxial shielding gas upon injection into the reactor.

Cryogenic cooling of exothermic reactor

A heat exchanger unit having a housing into which a cryogenic liquid is introduced and permitted to evaporate and vaporize into a cryogenic cold gas. A process fluid to be cooled flows in a heat exchanger and heat exchange to cool the process fluid takes place between the cold gas and the heat exchanger, without making direct contact between the cryogenic liquid and the heat exchanger which would cause freezing. The refrigerating capacity of the cryogenic cold gas is replenished by heat exchange contact with the evaporating cryogenic liquid.

Growing community of inventors

Livingston, NJ, United States of America

Alan T Cheng