Otsuka Pharmaceutical Company, Limited

Gw Pharma Limited

Gw Research Limited

Alan Sutton

Geoffrey W Guy

Stephen Wright

Tetsuro Kikuchi

Benjamin Whalley

Colin Stott

Vincenzo Di Marzo

Volker Knappertz

Marie Woolley-Roberts

Royston Gray

James Brodie

Daniela Parolaro

Luciano De Petrocellis

Rohini Rajyalaxmi Rana

Etienne De Meijer

Sofia Torres

Mar Lorente

Angelo Antonio Izzo

Gabriella Aviello

Aniello Schiano Moriello

Alessia Ligresti

Ruth Alexandra Ross

Lesley Ann Ford

Sharon Anavi-Goffer

Manuel Guzman

Guillermo Velasco

David Potter

Paola Massi

Katarzyna Lach-Falcone

Francesca Borrelli

Francesca Borelli

Cannabidiol (CBD) is a cannabinoid designated chemically as 2-[(IR,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol. Its empirical formula is CHOand its molecular weight is 314.46. CBD is a cannabinoid that naturally occurs in theL. plant. CBD is a white to pale yellow crystalline solid which is insoluble in water and soluble in organic solvents. The present invention encompasses the surprising recognition that certain CBD preparations which are prepared from a botanical origin are more effective in treating diseases or disorders than preparations of CBD which are synthetic or purified to the extent no other impurities in the form of other cannabinoids are present. Prior CBD compositions have been prepared such that no psychoactive components, e.g., tetrahydrocannabinol (THC), remain in the final CBD preparation. Surprisingly, the absence of such minor impurities reduces the efficacy of CBD treatment. Such CBD preparations are characterized by chemical components and/or functional properties that distinguish them from prior CBD compositions. One or more components of the preparations described herein provide an unexpectedly synergistic effect when utilized in combination.

Cannabidiol preparations and its uses

Cannabidiol (CBD) is a cannabinoid designated chemically as 2-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol. Its empirical formula is CHOand its molecular weight is 314.46. CBD is a cannabinoid that naturally occurs in theL. plant. CBD is a white to pale yellow crystalline solid which is insoluble in water and soluble in organic solvents. The present invention encompasses the surprising recognition that certain CBD preparations which are prepared from a botanical origin are more effective in treating diseases or disorders than preparations of CBD which are synthetic or purified to the extent no other impurities in the form of other cannabinoids are present. Prior CBD compositions have been prepared such that no psychoactive components, e.g., tetrahydrocannabinol (THC), remain in the final CBD preparation. Surprisingly, the absence of such minor impurities reduces the efficacy of CBD treatment. Such CBD preparations are characterized by chemical components and/or funtional properties that distinguish them from prior CBD compositions. One or more components of the preparations described herein provide an unexpectedly synergistic effect when utilized in combination.

This invention relates to the use of phytocannabinoids, either in an isolated form or in the form of a botanical drug substance (BDS) in the treatment of cancer. Preferably the cancer to be treated is cancer of the prostate, cancer of the breast or cancer of the colon.

Phytocannabinoids in the treatment of cancer

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Salisbury, United Kingdom

Alan Sutton