Vaxinnate Corporation

Merck + Co., Inc.

Alan R Shaw

Thomas J Powell

Langzhou Song

Lynda G Tussey

Yi Zhang

Ge Liu

Scott W Umlauf

Robert S Becker

Paul M Keller

Hui Zheng

Leonardus H Van Der Ploeg

Kathryn J Hofmann

Howard Y Chen

Myrna E Trumbauer

Beth A Arnold

Anthony J Conley

Jwu-Sheng Tung

David N Taylor

Mark D Yeager

N David Taylor

Compositions that include at least a portion of a flagellin and an antigen can be employed in methods that stimulate an immune response in a subject, in particular, a protective immune response in a subject. Compositions can be associated with particles and employed in the methods in relatively low doses to provide protective immunity to infection.

Deletion mutants of flagellin and methods of use

Compositions that include Toll-like Receptor 5 agonists and at least a portion of at least one viral antigen can be employed in methods that stimulate an immune response in a subject, in particular, a protective immune response in a subject. Compositions can be associated with particles and employed in the methods in relatively low doses to provide protective immunity to viral infection.

A process of purifying target molecules is described that involves the selection of ligands based on identifying, in real time, association and dissociation constants with a given target molecule; using this information to select at least one ligand that exhibit predetermined association and dissociation constants with a given target molecule; anchoring a quantity of ligand to an activated solid support; contacting a quantity of target molecules with the anchored ligand(s); removing low affinity target molecules from anchored ligand and eluting particularly pure target molecules.

Large scale affinity chromatography of macromolecules

Expression of human interleukin-1.beta. in a transgenic animal

Growing community of inventors

Cranbury, NJ, United States of America

Alan R Shaw