Ocuphire Pharma, Inc.

Ocularis Pharma, Inc.

Healthtech Services Corp.

Alan R Meyer

William H Pitlick

Mina Sooch

Konstantinos Charizanis

Bernhard Hoffmann

Aleandro DiGianfilippo

Stephen B Kaufman

Tamara L Sager

The invention provides methods, compositions, and kits containing an alpha-adrenergic antagonist, such as phentolamine, for use in monotherapy or as part of a combination therapy to treat patients suffering from presbyopia, mydriasis, and/or other ocular disorders.

Methods and compositions for treatment of presbyopia, mydriasis, and other ocular disorders

The invention provides aqueous ophthalmic solutions of phentolamine or pharmaceutically acceptable salts thereof, medical kits, and methods for using such ophthalmic solutions to improve visual performance in a patient. Exemplary aqueous ophthalmic solutions include those containing phentolamine mesylate, mannitol, sodium acetate, and water.

Aqueous ophthalmic solutions of phentolamine and medical uses thereof

The invention provides methods, compositions, and kits containing phentolamine for improving visual performance. In particular, the invention provides improvement in visual performance, such as improvement in visual acuity, by daily ophthalmic administration of a phentolamine solution to an eye of a patient at or near the bedtime of the patient for an extended duration while minimizing the occurrence of adverse side effects, such as eye redness during the patient's waking hours.

Methods and compositions for daily ophthalmic administration of phentolamine to improve visual performance

A medication delivery device measures a preselected physical parameter of a patient as well measures at least one preselected parameter in the patient's immediate environment that relates to the physical parameter. A control element compares the preselected physical parameter measured with the preselected environmental parameter measured. A first command signal is generated when a predetermined correlation exists between the two parameters, while a second command signal is generated when it does not. The command signal can be used to base a decision to dispense medication to the patient, or to change the patient's immediate environment.

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N. Riverside, IL, United States of America

Alan R Meyer