Georgetown University

University of Illinois

Mars, Incorporated

Mayo Foundation for Medical Education and Research

University of Pittsburgh

Other

H. Lee Moffitt Cancer Center and Research Institute, Inc.

The Johns Hopkins University

Washington University

The University of North Carolina at Chapel Hill

University of Chicago

The Children's Hospital of Philadelphia

Fidia-georgetown Institute for the Neurosciences

National Institutes of Health, a Component of the US Dept. of Health & Human Services

Arizona Board of Regents on Behalf of the University of Arizona

Alan P Kozikowski

Gian Luca Araldi

Leo J Romanczyk

Werner Tueckmantel

Joel Bergman

Alejandro V Villagra

Garth Powis

Marc E Lippman

Jarda T Wroblewski

Bin Chen

Jay Hans Kalin

Yan Xia

Anatoly Dritschilo

Mira Jung

Eduardo M Sotomayor

Karrune Veeraprasert Woan

Lixin Qiao

Irina Gaisina

Pavel A Petukhov

Fajun Nan

Werner Tückmantel

Darryl Hugh Steensma

Kyle Vincent Butler

Shaomeng Wang

Sida Shen

John L Musachio

Werner T&uuml;ckmantel

Martin Gilbert Pomper

Kenneth J Kellar

Sung Jin Cho

Bryan Leo Roth

Erminio Costa

Alan I Faden

Philip Connell

Wayne W Hancock

Jiazhong Zhang

Werner Tuckmantel

Brian Budke

Andreas Svennebring

Amir P Tamiz

Po-wai Yuen

Jianjun Cheng

Jayaraman Chandrasekhar

Joel R Walker

Christian Belmant

Dajun Yang

Yingxian Xiao

Haiying Sun

Marc Bonneville

Jean-Jacques Fournie

Alessandro Guidotti

Hong Fan

Michal Pawlowski

Miles P Smith

Yufeng Chen

Yuan-Ping Pang

Abdul H Faug

Dawei Ma

Werner T Uckmantel

Jianhua Liu

Hongbin Yuan

Wei Lv

Irina Gaysina

Jia Zhou

Zhi-Liang Wei

Phillip Dennis

John Brognard

Xingquan Ma

Wolfgang Alexander Hoepping

Leo J Romanczyk Jr

Marc Alix Peyrat

Arsen Gaysin

Lixin Qioa

Gang Chen

Irina N Gaisina

Kyle B Butler

The present disclosure provides compounds represented by Formula I: and pharmaceutically acceptable salts, solvates, e.g., hydrates, and prodrugs thereof, wherein X and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat diseases and conditions, e.g., cancer, wherein inhibition of HDAC provides a benefit.

Isoxazole hydroxamic acids as histone deacetylase 6 inhibitors

Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a neurological disease, traumatic brain injury, stroke, hypertension, malaria, an autoimmune disease, autism, autism spectrum disorders, and inflammation, also are disclosed.

HDAC inhibitors and therapeutic methods using the same

The present disclosure provides compounds represented by Formula (I): and pharmaceutically acceptable salts, solvates, e.g., hydrates, and prodrugs thereof wherein X and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula (I) for use to treat diseases and conditions, e.g., cancer, wherein inhibition of HDAC provides a benefit. 

Embodiments concern methods and small molecule compositions for selectively inhibiting RAD51-mediated D-loop formation while preserving RAD51's ability to form nucleoprotein filaments. The selective RAD51 D-loop formation activity inhibitors DNA repair while minimizing replication-associated toxicity in normal tissue.

Small molecules inhibitors of RAD51

Compounds that inhibit histone (HDACI) and/or activate Nrf2 and HIF, and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC and/or activation of Nrf2 and HIF provide a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a neurological disease, traumatic brain injury, stroke, hypertension, malaria, an autoimmune disease, autism, autism spectrum disorders, and inflammation, also are disclosed.

Nrf and HIF activators/HDAC inhibitors and therapeutic methods using the same

The present invention concerns methods and compositions involving inhibitors and of RAD51, a protein involved in homologous recombination. In some embodiments, there are methods for sensitizing cells to the effects of DNA damaging agents, which can have particular applications for cancer patients. In some embodiments of the invention, the RAD51 inhibitor is a small molecule that directly affects RAD51 activity, such as its ability to promote filament formation.

Methods and compositions involving RAD51 inhibitors

Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a neurological disease, traumatic brain injury, stroke, malaria, an autoimmune disease, autism, and inflammation, also are disclosed.

Tetrahydroquinoline substituted hydroxamic acids as selective histone deacetylase 6 inhibitors

Disclosed are 2-phenyl-cyclopropylmethanamines which are selective 5-HT(2C) receptor agonists and are used in the treatments of diseases and conditions wherein modulation of 5-HT(2C) receptors provides a benefit, such as obesity and psychiatric disorders.

Cyclopropylmethanamines as selective 5-HT(2C) receptor agonists

Disclosed are selective histone deactylase inhibitors (HDACi) that having Formula I. Methods of making and using these inhibitors for the treatment of cancer, in particular melanoma are also disclosed.

Selective histone deactylase 6 inhibitors

Disclosed are selective histone deactylase inhibitors (HDACi) that having Formula (I). Methods of making and using these inhibitors for the treatment of cancer, in particular melanoma are also disclosed. 

Disclosed are selective histone deactylase inhibitors (HDACi) that having Formula I. Specifically, the disclosed subject matter relates to compounds having activity as selective HDAC6 inhibitors, methods of making and using the compounds, and compositions comprising the compounds. In still further aspects, the disclosed subject matter relates to methods for treating oncological disorders in a patient. Methods of making and using these inhibitors for the treatment of cancer, in particular melanoma are also disclosed.

Growing community of inventors

Princeton, NJ, United States of America

Alan P Kozikowski