University of Massachusetts

Alan P Farwell

Jack L Leonard

Truncated thyroid hormone receptors &#x394;TR&#x3b1;1 and &#x394;TR&#x3b1;2 have been discovered to play a role in actin-based endocytosis, e.g., in the nervous system. The invention relates to methods of discovering ligands effective in modulating endocytosis and transgenic mice with altered expression of &#x394;TR&#x3b1;1 and &#x394;TR&#x3b1;2. The invention is useful for the discovery and testing of compounds for treating disorders of the nervous system such as depression.

Methods for identifying compounds that modulate &#x394;TR&#x3b1;2 activity

Truncated thyroid hormone receptors &Dgr;TR&agr;1 and &Dgr;TR&agr;2 have been discovered to play a role in actin-based endocytosis, e.g., in the nervous system. The invention relates to methods of discovering ligands effective in modulating endocytosis and transgenic mice with altered expression of &Dgr;TR&agr;1 and &Dgr;TR&agr;2. The invention is useful for the discovery and testing of compounds for treating disorders of the nervous system such as depression.

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West Boylston, MA, United States of America

Alan P Farwell