Boehringer Ingelheim International Gmbh

Alan Olague

Doris Riether

Renee M Zindell

Todd Bosanac

Lifen Wu

Alessandra Bartolozzi

Heather Tye

Zhidong Chen

Ho Yin Lo

Pui Leng Loke

Stephane De Lombaert

Weimin Liu

Tina Marie Morwick

John D Huber

Jonathon Alan Dines

Peter Allen Nemoto

Stéphane De Lombaert

The present invention relates to compound of formula (I): or pharmaceutically acceptable salts thereof, wherein R-R, A and HET are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Heterocyclic compounds as inhibitors of leukotriene production

The present invention relates to compound of formula (I): or pharmaceutically acceptable salts thereof, wherein R-Rare as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Oxadiazole inhibitors of leukotriene production

The present invention relates to compounds of formula (I): and pharmaceutically acceptable salt thereof, wherein Xto X, Rto R, A, B, D and m are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Indolizine inhibitors of leukotriene production

The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R-Rare as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

The present invention relates to compounds of formula (I) and (IA): and pharmaceutically acceptable salts thereof, wherein R-Rare as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

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Danbury, CT, United States of America

Alan Olague