The United States of America, as Represented by the Secretary, Department of Health and Human Services

Wake Forest University

Loma Linda University

Louisiana State University and Agricultural & Mechanical College

The Uab Research Foundation (the University of Alabama at Birmingham)

The United States of America as Represented by the Department of Health

Alan N Schechter

Mark Thomas Gladwin

Daniel B Kim-Shapiro

Gordon G Power

Richard O Cannon, Iii

Christian J Hunter

David J Lefer

Edward H Oldfield

Rakesh P Patel

Ryszard Marek Pluta

Griffin P Rodgers

Shu-Zhen Huang

Richard O Cannon

Ryszard Pluta

Richard Iii Cannon

It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.

Use of nitrite salts for the treatment of cardiovascular conditions

Treatment of specific cardiovascular conditions with nitrite

A simple, rapid and reliable method for diagnosis of thalassemia is described. The method comprises amplification of the cDNA by polymerase chain reaction and determining the ratio between .alpha. and .beta. hemoglobin chain mRNAs.

Simple, rapid and reliable method for detecting thalassemia

Growing community of inventors

Bethesda, MD, United States of America

Alan N Schechter