Massey University

Institut Pasteur

The New Zealand Meat Board

Wool Production Technologies Ltd.

Alan Murray

Christine Dupont

Christine DuPont

Jeremy Lawrence Rae

Brigitte Gicquel

Marina Gheorghiu

The present invention relates to an immunogenic polypeptide isolated fromsubspeciesand variants of the polypeptide. The polypeptide and variants may be used in vaccines against Johne's disease and in methods for detection of the disease. Antibodies against the polypeptide or variants may be used in diagnostic tests for Johne's disease. Also included are polynucleotides encoding the polypeptide and variants, and methods for preparing these.

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The invention provides a vaccine comprising secreted protein derived fromsubsp(M. ptb) substantially free of whole organisms of that species either dead or alive. The secreted protein may be obtained from a culture of M. ptb with the microorganisms being removed by centrifugation and subsequent filtration. The vaccine may be used for vaccination against Johne's disease.

Vaccine

The present invention relates to an immunogenic polypeptide isolated fromsubspecies paratuberculosis and variants of the polypeptide. The polypeptide and variants may be used in vaccines against Johne's disease and in methods for detection of the disease. Antibodies against the polypeptide or variants may be used in diagnostic tests for Johne's disease. Also included are polynucleotides encoding the polypeptide and variants, and methods for preparing these.

Immunogenic polypeptide isolated from mycobacterium avium subspecies paratuberculosis and uses thereof

The invention provides a vaccine comprising secreted protein derived fromsubsp() substantially free of whole organisms of that species either dead or alive. The secreted protein may be obtained from a culture ofwith the microorganisms being removed by centrifugation and subsequent filtration. The vaccine may be used for vaccination against Johne's disease.

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Palmerston North, New Zealand

Alan Murray