Micromass UK Limited

Waters Technologies Corporation

Alan Millar

Robert Stephen Plumb

Jose M Castro-Perez

Henry Y Shion

Giorgis Isaac

Tim Riley

Stephen Mcdonald

John Shockcor

The present disclosure relates, in part, to MS apparatus, methods, and/or software, having improved selectivity, sensitivity, specificity, resolution, mass accuracy and dynamic range over conventional MS technologies. In particular, the technology relates to apparatus, methods, and/or software wherein a combination of in-source fragmentation, ion mobility separation, and/or time-aligned parallel (TAP) sample ion fragmentations are utilized in mass spectrometry for the analysis of samples.

Methods and apparatus for performing mass spectrometry

A method of searching for potentially unknown metabolites of pharmaceutical compounds is disclosed. The accurate mass of a pharmaceutical compound will generally be known and can be rendered in the form of an integer nominal mass or mass to charge ratio component and a decimal mass or mass to charge ratio component. Possible metabolites are searched for on the basis of having a decimal mass or mass to charge ratio component which is substantially very similar to the decimal mass or mass to charge ratio of the parent pharmaceutical compound.

Mass spectrometry

Mass spectrometer

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Southborough, MA, United States of America

Alan Millar