Charterhouse Therapeutics Ltd.

Crawford Healthcare Holdings Limited

Alan Michael Happe

Maria Gabriella Santoro

Stanley Michael Roberts

Vasudev Jadhav

Paul Evans

Nicolette Christa Ross

Timothy James Snape

Jérôme Dauvergne

A compound comprising a cyclopentanone, cyclopentenone, cyclohexanone or cyclohexenone group, wherein a first ring carbon atom carries an &#x2014;SR substituent, R is a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl, aralkenyl, or aralkynyl group that, optionally, includes at least one heteroatom in its carbon skeleton, the remaining available ring carbon atoms are optionally substituted, and said compound either: &#x2014;(a) is more soluble in water at a temperature of 20-40&#xb0; C.; (b) is less lipophilic; and/or, (c) has a greater therapeutic index; or; (d) is less soluble in water at a temperature of 20-40&#xb0; C.; (e) is more lipophilic; and/or, (f) has a greater therapeutic index; than an equivalent cyclohex-2-en-1-one or cyclopent-2-en-1-one derivative in which a hydrogen atom replaces said &#x2014;SR group. 

Pharmaceutical compositions

A compound of formula (I) or (II): wherein A is hydrogen or CRR; Y and Z are each, independently, hydrogen or a halogen; X is &#x2014;NRR, or R; Ris hydrogen, or a substituted or unsubstituted alkyl or alkenyl group containing 1&#x2013;4 carbon atoms; when X is &#x2014;NRR, Ris a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl aralkenyl, or aralkynyl group, that optionally includes at least one heteroatom in its carbon skeleton and contains 1&#x2013;12 carbon atoms; when X is R, Ris an unsubstituted alkyl, alkenyl or alkynyl group, or a substituted or unsubstituted aryl, aralkyl aralkenyl, or aralkynyl group, that optionally includes at least one heteroatom in its carbon skeleton and contains 1&#x2013;12 carbon atoms; Ris a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl aralkenyl, or aralkynyl group, that optionally includes at least one heteroatom in its carbon skeleton and contains 1&#x2013;12 carbon atoms; Ris hydrogen, a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl aralkenyl, or aralkynyl group, that optionally includes at least one heteroatom in its carbon skeleton and contains 1&#x2013;12 carbon atoms, &#x2014;COOR, or &#x2014;COR; Ris hydrogen, or a substituted or unsubstituted alkyl or alkenyl group containing 1&#x2013;5 carbon atoms; Ris an unsubstituted alkyl, alkenyl, or alkynyl group, that contains 1&#x2013;4 carbon atoms; and, Ris an unsubstituted or halo-substituted alkyl, aryl, or aralkyl group, that contains 1&#x2013;12 carbon atoms 

Pharmaceutically useful compounds

Growing community of inventors

Canterbury, United Kingdom

Alan Michael Happe