Astrazeneca Ab

Alan Martin Birch

Andrew David Morley

Roger John Butlin

Andrew Stocker

Paul Robert Owen Whittamore

Paul David Kemmitt

Michael James Waring

Thorsten Nowak

Alleyn Thomas Plowright

Paul Michael Murray

William McCoull

Andrew Leach

Petra Johannesson

Craig Samuel Donald

Suzanne Saxon Bowker

Leonie Campbell

Clive Green

Per Olof Ryberg

Jan Magnus Johansson

Annika Ulrika Petersson

Udo Andreas Bauer

Alexander Tobias Noeske

Ragnar Hovland

Jonas Gunnar Barlind

DGAT-1 inhibitor compounds of formula (I), pharmaceutically-acceptable salts and pro-drugs thereof are described, together with pharmaceutical compositions, processes for making them and their use in treating, for example, obesity 

Substituted pyrazines as DGAT-1 inhibitors

Compounds of formula (I) or salts thereof, wherein A, and Rto Rare as defined in the specification, are DGAT-1 inhibitors and are thereby useful in the treatment of, for example, obesity. Processes to make compounds of formula (I) are also described. 

Pyrimido [4,5-B]-oxazines for use as DGAT inhibitors

Carbamoyl compounds as DGAT1 inhibitors 190

Compounds of formula (I), and salts and pro-drugs thereof: Formula (I) wherein for example Ris optionally substituted aryl or heteroaryl; Y is a linking group selected from, for example, a direct bond, and a (substituted) alkyl chain; Ris an optionally substituted aryl, an optionally substituted cycloalkyl or an optionally substituted heterocyclic group; are described. Processes to make such compounds and their use as DGAT inhibitors, for example in the treatment of obesity, are also described. 

Oxadiazole derivative as DGAT inhibitors

Pyrimido [4,5-B] -Oxazines for use as DGAT inhibitors

Heterocyclic amides of formula (1) wherein:

Heterocyclic amide derivatives as inhibitors of glycogen phosphorylase

Heterocyclic amides of formula (1) wherein: is a single or double bond;

Indole-amide derivatives and their use as glycogen phosphorylase inhibitors

Heterocyclic amide derivatives as inhibitors of glycogen phoshorylase

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Macclesfield, United Kingdom

Alan Martin Birch