Cor Therapeutics, Inc.

Millennium Pharmaceuticals Limited

Alan M Laibelman

Robert M Scarborough

Bing-Yan Zhu

Uma Sinha

Charles K Marlowe

Pamela B Conley

Neill A Giese

Hans-Michael Jantzen

Larry J Fretto

Nathalie Lokker

Platelet ADP receptor inhibitors

Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

Inhibitors of factor Xa

Inhibitors of factor XA

A method for selectively inhibiting a kinase is disclosed, which comprises contacting a composition containing a kinase with a compound of the formula: ##STR1## wherein: R.sub.1 is lower alkyl, lower hydrocarbyl, aryl lower alkyl, heteroaryl lower alkyl, 5- or 6-membered heterocyclic aromatic, polyaromatic, polyaromatic carbonyl, polyheteroaromatic or polyheteroaromatic carbonyl; R.sub.2 is lower alkyl, lower hydrocarbyl, aryl lower alkyl, heteroaryl lower alkyl, 5- or 6-membered heterocyclic aromatic, lower hydrocarboyl, 5- or 6-membered heterocyclic aromatic carbonyl, polyaromatic or polyheteroaromatic; R.sub.3 is H or lower alkyl; R.sub.5 is H, lower alkyl, lower hydrocarbyl, aryl lower alkyl, heteroaryl lower alkyl, 5- or 6-membered heterocyclic aromatic, halogen, or cyano; and R.sub.6 is H or lower hydrocarboyl.

Pharmaceutical pyrazole compositions useful as inhibitors of protein

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Menlo Park, CA, United States of America

Alan M Laibelman