Alcon Laboratories, Inc.

Alcon Research, Ltd.

Escalon Ophthalmics, Inc.

Other

Escalon Medical Corporation

Alan L Weiner

Sohrab Darougar

Cody Yarborough

Bhagwati P Kabra

Ernesto J Castillo

Onkar N Singh

L Wayne Schneider

Victor Albert Raul

David Clayton Gantner

David Allen Marsh

Ruma P Sarkar

Rajan Bawa

Shivalik Bakshi

William E McCune

Julia A Clifford

Youqin Tian

Padmanabh Pravinchandra Bhatt

Subhash C Airy

Larry Smith, Ii

Sterling Johnson

Kevin Sinnett

Theron R Rodstrom

Ii Larry Smith

The present invention concerns implantable ocular devices for the sustained release of medication to the eye, and methods for manufacturing and using such devices. In one embodiment, the present invention provides a device comprising: (a) a body comprising a matrix of a prostaglandin and a silicone; (b) a parylene coating on the outer surface of the body; and (c) one or more pores extending from the outer surface of the parylene coating to the outer surface of the body.

Punctal plugs and methods of delivering therapeutic agents

The present invention is directed to a pulsatile ophthalmic peri-corneal drug delivery device. The device includes an annular body and a mechanism for releasing multiple separate and distinct doses of a therapeutic composition over an extended period of time.

Pulsatile peri-corneal drug delivery device

This invention relates to reduced stinging, sustained release ophthalmic formulations and the method of treatment comprising administering such formulations topically to the eye when in need thereof.

Sustained release, and comfortable opthalmic composition and method for ocular therapy

A pharmaceutical product comprising an aqueous prostaglandin formulation and a polypropylene container are disclosed. Aqueous prostaglandin formulations are more stable in polypropylene containers than polyethylene containers.

Prostaglandin product

The use of polyethoxylated castor oils in prostaglandin compositions enhances the prostaglandin's chemical stability.

Storage-stable prostaglandin compositions

A flexible ocular insert device adapted for the controlled sustained release of an ophthalmic drug into the eye. In one embodiment, the device includes an elongated body of a polymeric material in the form of a rod or tube containing a pharmaceutically active ingredient and with at least two anchoring protrusions extending radially outwardly from the body. The device has a length of at least 8 mm and the diameter of its body portion including the protrusions does not exceed 1.9 mm. The sustained release mechanism may, for example, be by diffusion or by osmosis or bioerosion. The insert device is advantageously inserted into the upper or lower fornix of the eye so as to be independent of movement of the eye by virtue of the fornix anatomy. The protrusions may be of various shapes such as, for example, ribs, screw threads, dimples or bumps, truncated cone-shaped segments or winding braid segments. In a further embodiment, the polymeric material for the body is selected as one which swells in a liquid environment. Thus a device of smaller initial size may be employed. The present insert device is of a size and configuration such that, upon insertion into the upper or lower fornix, the device remains out of the field of vision so as to be well retained in place and imperceptible by a patient over a prolonged period of use. The device can be retained in the upper or lower fornix for 7 to 14 days or longer.

Ocular insert with anchoring protrusions

A tack for intraocular drug delivery and a method for insertion and removal of an intraocular device for sustained release of a drug are provided. The tack comprises a post, an anchoring region and a head. The post is for being positioned within the vitreous region of the eye. The post has a first end and a second end, and includes a drug to be administered. The anchoring region is affixed to the second end of the post, and includes a width measured perpendicularly to a longitudinal axis of the tack which varies to provide the anchoring region with a configuration to anchor the tack within at least one of a sclera, a retina and a choroid. The head extends radially outwardly from the anchoring region such that upon insertion of the anchoring region and post within the eye, the head remains external to the eye and abuts a scleral surface of the eye. Other embodiments include a tack comprising a post, a central portion, a head and a suture hole through the head for anchoring the head to the sclera. Alternatively the tack comprises a post having a first portion of liquid drug, a hollow central portion filled with a second portion of liquid drug in fluid communication with the post and a head with an opening which allows for injection of subsequent doses of liquid drug through the head into the central portion.

Tack for intraocular drug delivery and method for inserting and removing

Growing community of inventors

Arlington, TX, United States of America

Alan L Weiner