USA As Represented by Secretary of the Navy

Other

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Alan L Huston

Brian L Justus

Igor L Medintz

Alan Lawrence Justus

Barbara A Marcheschi

Kimihiro Susumu

James B Delehanty

Jeffrey R Deschamps

Philip E Dawson

Michael H Stewart

Eunkeu Oh

Alexander L Efros

Okhil Nag

Anthony J Campillo

Lauren D Field

W Russ Algar

Niko Hildebrandt

Charles D Merritt

Mladen Barbic

John J Macklin

Robert E Miller

Parag Chitnis

Paul Falkenstein

Luis A Benevides

Nashaat Rasheed

John R Cressman

Bertalan K Andrasfalvy

Marko Moscovitch

C Norman Coleman

Rosemary Altemus

Holly Ning

Brian I Justus

A copper-doped glass formed by placing a target glass in a container, surrounding the target glass with a powder mixture comprised of SiOpowder and CuS powder, wherein the SiOpowder and the CuS powder are mixed according to the formula (SiO)(CuS), where 0.01&#x3c;x&#x3c;0.1, and heated to a temperature of between 800&#xb0; C. and 1150&#xb0; C. for a duration of between 1 and 10 hours.

Method of manufacture of copper-doped glasses

A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be Cfullerene. Emission correlates with cellular membrane potential.

Modular, multifunctional nanoparticle-based bioconjugate for realtime visualization of cellular membrane potential

A method of making a copper-doped glass comprising placing a target glass in a container, placing a target glass in a container, surrounding the target glass with a powder mixture comprised of fused silica (SiO) powder and copper sulfide (CuS) powder, such that both the target glass and the surrounding powder are contained in the container, and heating the container and the target glass and the surrounding powder mixture to a temperature of between 800&#xb0; C. and 1150&#xb0; C.

Compositions including additive manufacturing materials incorporating radiological detection materials therein are provided. Also provided are apparatus and methods, which may be utilized to monitor and measure nuclear criticality events, and determine if personnel have been exposed to ionizing radiation. The compositions, apparatus, and methods beneficially improve accuracy in assessing radiation exposure, particularly neutron exposure, and reduce degradation of the radiological detection materials.

Radiological criticality dosimeter using nanoparticle technology in additive manufacturing

A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be Cfullerene. Photoacoustic emission from the construct correlates with cellular membrane potential.

Multifunctional nanoparticle bioconjugates for photoacoustic-based recording of cellular membrane potential

AHelium gas counter comprising a container, a gas tube within the container, and a mixture ofHelium and Xenon or a mixture ofHelium and Krypton. A method of making aHelium gas counter comprising providing a container, placing a gas tube within the container, and depositing a mixture ofHelium and Xenon or a mixture ofHelium and Krypton into the gas tube.

[object Object]

A copper dopant delivery powder comprising a fused silica powder and a CuS powder. A method of making the copper dopant delivery powder. A method of making a copper-doped glass comprising placing a target glass in a container, packing a composite SiO.CuS dopant powder around the target glass and heating the container and SiO.CuS dopant powder to a temperature of between 800&#xb0; C. and 1150&#xb0; C. A copper-doped glass comprising a glass comprising copper-doping wherein the copper-doped glass was formed by covering the glass with a fused silica powder and a CuS powder, wherein the fused silica powder and the CuS powder are mixed in varying ratios of CuS to silica represented by the formula (SiO)(CuS)and heating to a temperature of between 800&#xb0; C. and 1150&#xb0; C.

Copper-doped glasses and methods of manufacture

A glass pipette such as an electrode for electrophysiological recording is coated with quantum dots. This greatly aids the ability to observe the glass pipette, particular in tissue as the quantum dots provide an excellent performance under two-photon illumination used to visualize objects at depths of hundreds of microns.

Coatings of semiconductor quantum dots for improved visibility of electrodes and pipettes

AHelium gas counter comprising polyethylene slabs, a rectangular gas tube within the polyethylene slabs, and a mixture ofHelium and Xenon. AHelium gas counter comprising polyethylene slabs, a rectangular gas tube within the polyethylene slabs, and a mixture ofHelium and Krypton. A method of making aHelium gas counter comprising providing polyethylene slabs, placing a rectangular gas tube within the polyethylene slabs, and depositing a mixture ofHelium and Xenon into the rectangular gas tube.

Described herein is a time-gated, two-step FRET relay effective to provide temporal transference of a prompt FRET pathway, or provide spectro-temporal encoding analytical signals and other information. A FRET relay assembly includes a long lifetime FRET donor (for example, a lanthanide complex), a semiconductor quantum dot (QD) configured as an intermediate acceptor/donor in FRET, and a fluorescent dye configured as a terminal FRET acceptor, wherein the long lifetime FRET donor has an excited state lifetime of at least one microsecond and the QD and fluorescent dye each have excited state lifetimes of less than 100 nanoseconds.

Spectro-temporal optical encoding of information using a time-gated fluorescence resonance energy transfer (FRET)

A device having: a scintillator material, an optically transparent element containing a glass or polymer and gadolinium oxide, and one or more photomultiplier tubes adjacent to the scintillator material. The optically transparent element is surrounded by the scintillator material.

Neutron detector

An improved thermoluminescence dosimeter (TLD) system, which includes a TLD reader configured to produce data indicative of a radiation exposure, one or more dosimeters comprising a dosimeter substrate coated with a thin layer of a light-absorbing material, a light stimulation source configured to heat the dosimeter using light incident on the dosimeter coating, a light detection system to detect TL emission and an appropriately programmed computer configured to analyze data from the reader and to output data indicative of an extent of radiation exposure.

Laser-heated thermoluminescence dosimeter

An optically stimulated luminescence (OSL) dosimeter system. An OSL reader configured to produce data indicative of a radiation exposure, one or more OSL dosimeters fabricated from a thermoluminescent material, a light stimulation source configured to stimulate the OSL dosimeter to produce luminescence emissions, and a light-detection system that measures the intensity of such luminescence emissions and converts the electrical signal to a binary string that can be processed by an appropriately programmed computer configured to analyze data from the reader and produce data indicative of an extent of radiation exposure. Dose information is obtained without requiring heating of the dosimeter. The dosimeter can be interrogated multiple times with minimal loss of dose information.

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Aldie, VA, United States of America

Alan L Huston