Massachusetts Institute of Technology

Harvard College

Other

Children's Medical Center Corporation

Alan L Davison

Alun G Jones

Michael J Abrams

Clay Owens

Chris Clouse

Ashfaq Mahmood

John Lister-James

James Kronauge

Peter C Meltzer

Peter T Lansbury

James Douglas Harper

Bertha K Madras

Paul Blundell

Matthias Friebe

Cristina Bolzati

Jerry George McGarrah

Hogyu Han

David Brenner

Cheon-Gyu Cho

Weiguo Zhen

A hand disassembly rotational valve coupling for tool less manipulation by a user's hands and fingers using a coupling housing body defining an output seal aperture close to an output handle retention slot and slot lip, where the slot lip has a slot handle gap and an output seal retainer including a coupling handle ring with a first triangulated offset body retention ears and hand graspable handles separated by a ring handle gap for hand assembly and disassembly from the coupling housing body.

Toolless disassembly rotational vacuum coupling

A split body, rotary C gate, removeable stem vacuum valve using an input assembly with handle extensions that allow for hand movement of the incoming pipe to access an inner aperture body with a curved sealing face that directly seals to a C shaped gasketless gate that can be rotated into and out of the inner body aperture for easy cleaning. The gasketless gate is held in position using gate axles with an outer axle stem connected to a polygon lower body that mates into a matching polygon aperture on the gasketless gate. The middle valve assembly's gasketless housing body defines upper and lower axle washer pockets for locating the axles for proper operation and simple axle pins for securing the axles in position.

Split body, rotary C gate, removeable stem, vacuum valve

The present invention relates to compounds and related technetium and rhenium complexes thereof which are suitable for imaging or therapeutic treatment of tumors, e.g., carcinomas, melanomas and other tumors. In another embodiment, the invention relates to methods of imaging tumors using radiolabeled metal complexes. Preferred radiolabeled complexes for imaging tumors include technetium and rhenium complexes. The high tumor uptake and significant tumor/nontumor ratios of the technetium complexes of the invention indicate that such small technetium-99m-based molecular probes can be developed as in-vivo diagnostic agents for melanoma and its metastases. In yet another embodiment, the invention relates to methods of treatment of tumors using a radiolabeled metal complex as a radiopharmaceutical agent to treat the tumor.

Small technetium-99m and rhenium labeled agents and methods for imaging tumors

An apparatus for vacuum transferring food product having a hopper for retaining food product, the hopper including a discharge port; a vacuum chamber having an inlet and an outlet, wherein the inlet is coupled to the hopper at the hopper's discharge port; a vacuum source for inducing a vacuum pressure between the hopper and the vacuum chamber so as to cause food product retained by the hopper to be drawn into the vacuum chamber though the inlet; a first timing circuit for controlling the length of time that the vacuum pressure is to be applied between the hopper and the vacuum chamber; and a second timing circuit for controlling the rate at which the food product is dispensed from the outlet. The first timing circuit may be adjusted to increase or decrease the length of time that the vacuum pressure is drawn though the apparatus, and the second timing circuit may be adjusted to increase or decrease the frequency of the opening of the outlet.

Vacuum transfer apparatus and process

Radiopharmaceutical compounds are disclosed. A tropane compound is linked through the N atom at the 8-position to a chelating ligand capable of complexing technetium or rhenium to produce a neutral labeled complex that selectively binds to the dopamine transporter. These compounds can be prepared as separate diastereoisomers as well as a mixture of diastereoisomers. Also disclosed are radiopharmaceutical kits for preparing the labeled radiopharmaceutical compounds.

Dopamine transporter imaging agent

Novel organometallic compounds for binding amyloid are described. Methods using such compounds for determining by imaging the localization or quantification of amyloid fibrils in a mammal, for diagnosing the degree of progression of Alzheimer's disease in a mammal, for monitoring the response to a therapy in a mammal having Alzheimer's disease, for identifying an agent useful for treating Alzheimer's disease, for treating Alzheimer's disease, and for detecting the presence of the infectious form of the prion protein, are also described.

Organometallic ligands for the localization and quantification of

A coordination complex comprising a radionuclide selected from the class consisting of radioactive isotopes of Tc, Ru, Co, Pt and Re and an isonitrile ligand of the formula:

Carboxy, carboalkoxy and carbamile substituted isonitrile radionuclide

A method for preparing radiopharmaceutical complexes that are substantially free of the reaction materials used to produce the radiopharmaceutical complex is disclosed. The method involves admixing in a suitable first solvent in a container a target seeking ligand or salt or metal adduct thereof, a radionuclide label, and a reducing agent for said radionuclide, thereby forming said radiopharmaceutical complex; coating the interior walls of the container with said pharmaceutical complex; discarding the solvent containing by-products and unreacted starting reaction materials; and removing the radiopharmaceutical complex from said walls by dissolving it in a second solvent, thereby obtaining said radiopharmaceutical complex substantially free of by-products and unreacted starting materials.

Method for preparing radiopharmaceutical complexes

A bisamide-bisthiol ligand containing fatty acid substituted thiol useful for producing Tc-labelled radiodiagnostic imaging agents is described. The ligand forms a complex with the radionuclide .sup.99m Tc suitable for administration as a radiopharmaceutical to obtain images of the heart for diagnosis of myocardial disfunction.

Technetium radiodiagnostic fatty acids derived from bisamide bisthiol

A method for preparing a coordination complex of an isonitrile ligand and radionuclide such as Tc, Ru, Co, Pt, Fe, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Nb and Ta is disclosed. The method comprises preparing a soluble metal adduct of said isonitrile ligand by admixing said ligand with a salt of a displaceable metal having a complete d-electron shell selected from the group consisting of Zn, Ga, Cd, In, Sn, Hg, Tl, Pb and Bi to form a soluble metal-isonitrile salt, and admixing said metal isonitrile salt with a salt comprising said radioactive metal in a suitable solvent to displace said displaceable metal with the radioactive metal thereby forming said coordination. The complex is useful as a diagnostic agent for labelling liposomes or vesicles, and selected living cells containing lipid membranes, such as blood clots, myocardial tissue, gall bladder tissue, etc.

Metal-isonitrile adducts for preparing radionuclide complexes for

A radiodiagnostic bisamido-bisthio ligand useful for producing Tc-labelled radiodiagnostic renal agents is described. The ligand forms a complex with the radionuclide .sup.99m Tc suitable for administration as a radiopharmaceutical to obtain images of the kidney for diagnosis of kidney disfunction.

Bisamide bisthiol compounds useful for making technetium radiodiagnostic

A coordination complex of an isonitrile ligand and radionuclide such as Tc, Ru, Co, Pt, Fe, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Nb and Ta, is useful as a diagnostic agent for labelling liposomes or vesicles, and selected living cells containing lipid membranes, such as blood clots, myocardial tissue, gall bladder tissue, etc.

Growing community of inventors

Lowell, AK, United States of America

Alan L Davison