Warner-lambert Company

Pfizer Corporation

Alan Kraker

William Alexander Denny

Andrew Mark Thompson

Alexander James Bridges

Gordon William Rewcastle

David W Fry

Robert Frederick Meyer

Brian Desmond Palmer

Howard D Showalter

Ellen Myra Dobrusin

Jeffrey Bruce Smaill

Richard John Booth

Howard Daniel Hollis Showalter

Ho Huat Lee

Lorna Helen Mitchell

Florence Oliver Joseph McCarthy

This invention relates to pyrrolocarbazole derivatives according formula I wherein R, R, R, R, R, X and Y are as defined in the specification wherein said derivatives specifically inhibit one or both of the checkpoint kinases Wee1 and Chk1 

Inhibitors of checkpoint kinases (Wee1 and Chk1)

Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family

Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family

Described are compositions and a method of inhibiting epidermal growth factor receptor tyrosine kinase by treating, with an effective inhibiting amount, a mammal, in need thereof, a compound of Formula II:

Novel 4-substituted amino pyrido [3,2-d]pyrimidine inhibitors of epidermal growth factor receptor family of tyrosine kinases are described, as well as pharmaceutical compositions of the same, which are useful in treating proliferative diseases such as cancer, synovial pannus invasion in arthritis, psoriasis, vascular restenosis and angiogenesis and additionally useful in the treatment of pancreatitis and kidney disease as well as a contraceptive agent.

Substituted pyrido[3,2-d]pyrimidines capable of inhibiting tyrosine

Novel 4-substituted amino benzothieno�3,2-d!pyrimidine and 4-substituted amino�2,3-d!pyrimidine inhibitors of epidermal growth factor receptor family of tyrosine kinases are described, as well as pharmaceutical compositions of the same, which are useful in treating proliferative diseases such as cancer, synovial pannus invasion in arthritis, psoriasis, vascular restenosis and angiogenesis and additionally useful in the treatment of pancreatitis and kidney disease as well as a contraceptive agent.

Tricyclic compounds capable of inhibiting tyrosine kinases of the

Novel 4-substituted amino pyrido pyrimidine and 4-substituted amino pyrido pyrimidine inhibitors of epidermal growth factor receptor family of tyrosine kinase are described, as well as pharmaceutical compositions of the same, which are useful in treating proliferative diseases such as cancer, synovial pannus invasion in arthritis, psoriasis, vascular restenosis and angiogenesis and additionally useful in the treatment of pancreatitis and kidney disease as well as a contraceptive agent.

Bicyclic compounds capable of inhibiting tyrosine kinases of the

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Ann Arbor, MI, United States of America

Alan Kraker