Purdue Research Foundation

Alan Keith Jarmusch

Robert Graham Cooks

Ahmed Mohamed Hamid

Zheng Ouyang

Valentina Pirro

Livia Schiavinato Eberlin

Kevin Scott Kerian

The invention generally relates to systems and methods for sample analysis using swabs. In certain aspects, the invention provides systems that include a probe having a conductive proximal portion coupled to a porous material at a distal portion of the probe that is configured to retain a portion of a sample that has contacted the porous material, and a mass spectrometer having an inlet. The system is configured such that the porous material at a distal portion of the probe is aligned over the inlet of the mass spectrometer.

Systems and methods for sample analysis using swabs

The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples.

Mass spectrometry analysis of microorganisms in samples

The invention generally relates to methods for analyzing a metabolite level in a sample. In certain embodiments, methods of the invention may involve obtaining a sample, analyzing the sample using a mass spectrometry technique to determine a level of at least one metabolite in the sample, and correlating the metabolite level with an originating source of the sample, thereby analyzing the sample.

Methods for determining a tumor margin in a tissue using a desorption electrospray ionization (desi) technique

The invention generally relates to methods for analyzing an analyte in a sample that involve providing a capture module, the module configured to capture an analyte from a sample in an ambient environment and generate ions of the analyte, wherein the capture module comprises a cartridge and a porous substrate within the cartridge that is connected to a voltage source; and generating ions of the analyte from the capture module that are analyzed in a mass analyzer operably coupled to the capture module, thereby analyzing the analyte in the sample.

The invention generally relates to methods for analyzing an analyte in a sample. In certain embodiments, the methods involve providing a capture module, the module configured to capture an analyte in a sample in an ambient environment and generate ions of the analyte, wherein the capture module comprises a cartridge and a porous substrate within the cartridge that is connected to a voltage source, and wherein the porous substrate further comprises an internal standard; capturing the analyte in the sample to the porous substrate of the capture module; generating ions of the analyte and the internal standard held by the porous substrate via the voltage source that is coupled to the porous substrate; and analyzing the generated ions of the analyte and the internal standard in a mass analyzer that is operably coupled to the capture module.

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Lafayette, IN, United States of America

Alan Keith Jarmusch