Neurex Corporation

Elan Pharmaceuticals, Inc.

Alan Justice

Karen L Valentino

Kishor Chandra Gohil

Tejinder Singh

George P Miljanich

A method of producing analgesia in nociceptive and neuropathic pain is disclosed. The method includes administering to a subject an omega conopeptide which is characterized by its ability to (a) inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind selectively to omega conopeptide MVIIA binding sites present in neuronal tissue. Also disclosed are novel omega conotoxin peptides effective in producing analgesia.

Method for enhancing analgesia

Method of selecting a compound for producing analgesia

Method of treating inflammation

Methods for producing analgesia

Disclosed are novel omega conotoxin peptides effective in producing analgesia.

Omega conopeptide compositions

A method of producing analgesia and enhancing opiate analgesia is disclosed. The method includes administering TVIA (SNX-185) or MVIIA (SNX-111) omega-conopeptide, or derivative thereof which is characterized by its ability to (a) inhibit voltage-gated calcium channels selectively in neuronal tissue, as evidenced by the peptide's ability to inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind to omega-conopeptide MVIIA binding sites present in neuronal tissue.

Method of producing analgesia

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Sunnyvale, CA, United States of America

Alan Justice