Syngenta Corporation

Zeneca Limited

Syngenta Crop Protection, Inc.

Alan John Whitton

Raymond Vincent Jones

Ewan Campbell Boyd

David John Ritchie

Raymond Vincent Heavon Jones

Jennifer Ann White

Jack Hugh Vass

Colin John Bennie

Ian George Fleming

Alexander P Fung

Michael Charles Standen

Brian Geoffrey Cox

David D Friese

Peter Karl Wehrenberg

Joanne Emma Murray

Robin Fieldhouse

Erwin Michael Seidel

Alastair Lain Stewart

John Desmond Hunt

Samuel McNeish

Robert Comgall Ewins

David Alan Glanville

Timothy John Doyle

Paul Richard Evans

Gareth Andrew De Boos

Ian Gordon Berry

Logan Thomson Nisbet

Kirstin Maccormick

Julie Forrester

Susan Thomson Hamilton

Alastair Iain Currie Stewart

Pascal Bugnon

Gillan Beveridge

Gillian Beveridge

Jack Hugh Vaas

Jack Vass

The present invention relates, inter alia, to a process for preparing a compound of formula (I): using, as a catalyst 1,4-diazabicyclo[2.2.2]octane. 

Preparation of azoxystrobin

The present invention relates, inter alia, to a process for preparing a compound of formula (I): using a quinuclidine-based catalyst or an optionally 3-substituted N-methyl pryrrolidine-based catalyst. 

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The present invention relates, inter alia, to a process for preparing a compound of formula (I): which comprises either (a) reacting a compound of formula (II): with 2-cyanophenyl, or a salt thereof, in the presence of between 0.1 and 2 mol % of 1,4-diazabicyclo[2.2.2]octane, or (b) reacting a compound of the formula (III): with a compound of the formula (IV): in the presence of between 0.1 and 2 mol % of 1,4-diazabicyclo[2.2.2]octane; where W is the methyl (E)-2-(3-methoxy)acrylate group C(COCH)&#x2550;CHOCHor the methyl 2-(3,3-dimethoxy)propanoate group C(COCH)CH(OCH), or a mixture of the two groups. In addition, the present invention relates to a novel precursors of the compound of formula (I) and methods for making them. 

Processes for the preparation of azoxystrobin using dabco as a catalyst and novel intermediates used in the processes

3-Isochromanone is prepared by partially chlorinating o-tolylacetic acid with sulphuryl chloride or chlorine gas in an inert organic solvent in the presence of a free radical initiator. The 2-chloromethylphenylacetic acid first obtained is converted to 3-isochromanone by treatment with a base and separated from unreacted o-tolylacetic acid, which is in the form of a salt, by a phase separation technique. The separated o-tolylacetic acid salt is converted to o-tolylacetic acid by controlled acidification and the o-tolylacetic acid is extracted for re-use. The invention reduces the formation of unwanted, over-chlorinated by-products and leads to a more efficient process.

Chemical process

A process for extracting from aqueous solution the alkali metal or calcium salt of a halo or haloalkyl substituted 2-hydroxypyridine, or a 2-hydroxyquinoline or 2-hydroxybenzothiazole which comprises contacting an aqueous alkaline or neutral solution of the alkali metal or calcium salt, in which is dissolved an alkali metal fluoride, chloride, bromide, hydroxide, sulphate, sulphite, cyanate, cyanide, thiocyanate, thiosulphate, sulphide, phosphate, hydrogen phosphate, carbonate, bicarbonate, borate, chlorate, hypochlorite, perchlorate, nitrite, chromate, dichromate or permanganate or calcium chloride, bromide, nitrate, nitrite, chlorate, hypochlorite, perchlorate, thiocyanate, thiosulphate, chromate, dichtromate or permanganate, with a partially water-miscible organic solvent so as to transfer aqueous solution of the alkali metal or calcium salt of the 2-hydroxypyridine, 2-hydroxyquinoline or 2-hydroxybenzothiasole into the solvent whilst retaining separate aqueous and solvent phases, and thereafter separating the solvent phase containing the alkali metal or calcium salt and water from the aqueous phase, the ratio of solvent to water in the separated solvent phase being from 0.5:1 to 10:1 w/w.

Chemical process for the extraction of 2-hydroxy pyridine derivatives, 2-hydroxyquinoline, and 2-hydroxybenzothiazole

A process for the preparation of 3-isochromanone which comprises contacting an o-xylene-&#x3b1;,&#x3b1;'-dihalide with carbon monoxide, in the presence of a catalyst and a hindered amine base in a liquid medium comprising water and a tertiary alcohol.

Process for preparing 3-isochromanone

Process for the preparation of pyrimidine compounds

4,6-Dichloropyrimidine is prepared by treating 4,6-dihydroxypyrimidine with a chlorinating agent of the formula R.sup.1 R.sup.2 R.sup.3 PCl.sub.2 wherein R.sup.1, R.sup.2 and R.sup.3 are independently alkyl or aryl, or one or more of the groups R.sup.1, R.sup.2 and R.sup.3 is linked to a polymer support. Conveniently, the chlorinating agent may be prepared in situ by reacting the corresponding phosphine oxide with phosgene. Thus, in a preferred process, 4,6-dichloropyrimidine is prepared by treating 4,6-dihydroxypyrimidine with phosgene in the presence of a phosphine oxide.

Process for preparaing (E)-methyl

A process for the preparation of 2-hydroxy-6-trifluoromethylpyridine which comprises reacting 2-fluoro-6-trifluomethylpyridine or a mixture of 2-fluoro-6-trifluoromethylpyridine and 2-chloro-6-trifluoromethylpyridine with an alkali metal hydroxide at a temperature of from 50.degree. C. to 160.degree. C. and acidifying the product so formed.

Process for preparing 4,6-dichloro-pyrimidine

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Alan John Whitton