Massachusetts Institute of Technology

Other

Alan J Grodzinsky

Eliot H Frank

David L Bombard

Emerson Cheung Quan

David Breslau

Steven Treppo

Moungi G Bawendi

Rohit Nandkumar Karnik

Cliff Richard Wong

Ambika Goel Bajpayee

Martin L Yarmush

Shuguang Zhang

Kamal Youcef-Toumi

Iman Soltani Bozchalooi

Christine Ortiz

Han Hwa Hung

Vicki Chin

Paul E Grimshaw

Hadi Tavakoli Nia

Evan P Salant

John Kisiday

Norman A Shoenfeld

Paula Ragan

Microparticles and nanoparticles and compositions thereof are provided. The microparticles and nanoparticles and compositions may be used for the treatment of musculoskeletal disease, such as osteoarthritis and injury such as trauma.

Surface binding of nanoparticle based drug delivery to tissue

Microparticles and nanoparticles and compositions thereof are provided. The microparticles and nanoparticles and compositions may be used for the treatment of musculoskeletal disease, such as osteoarthritis and injury.

Rheology system. The system includes a first piezoelectric actuator assembly for providing microscale displacement of a sample and a second piezoelectric actuator assembly for oscillating the sample at a nano/micro scale displacement in a selected frequency range extended significantly as compared to the frequency range available on the commercial AFMs. A preferred sample is cartilage and the disclosed system can distinguish between normal cartilage and GAG-depleted cartilage.

High-frequency rheology system

The invention features peptide scaffolds that are useful in the repair and replacement of various tissues. The invention also provides methods for making these scaffolds and methods for using them.

Macroscopic scaffold containing amphiphilic peptides encapsulating cells

The change in tissue impedance due to the change in the extracellular matrix that results from the degradation of cartilage is utilized to detect degradation of articular cartilage. A probe includes electrodes that apply a current to the articular cartilage which results in a current distribution and electric field within the cartilage, along with an associated voltage drop across the electrodes. The amplitude of this voltage drop is then measured and divided by the current applied to determine the tissue impedance. By measuring the impedance of patient tissue and comparing the detected patient impedance to a normal value for the tissue from clinically normal tissue, a determination of whether the patient tissue is degraded, and a determination of the extent of degradation is possible. Preferably, the impedance is measured using a probe with interdigitated electrodes. By changing which electrodes are utilized, the wavelength of the current distribution changes, allowing the probe to image depth dependent focal lesions.

Arthroscopic impedance probe to detect cartilage degeneration

The change in tissue impedance due to the change in the extracellular matrix that results from the degradation of cartilage is utilized to detect degradation of articular cartilage. A probe comprising electrodes is applies a current to the articular cartilage which results in a current distribution and electric field within the cartilage, along with an associated voltage drop across the electrodes. The amplitude of this voltage drop is then measured and divided by the current applied to determine the tissue impedance. By measuring the impedance of patient tissue and comparing the detected patient impedance to a normal value for the tissue from clinically normal tissue, a determination of whether the patient tissue is degraded and the extent of degradation is possible. Preferably, the impedance is measured using a probe with interdigitated electrodes. By changing which electrodes are utilized, the wavelength of the current distribution changes, allowing the probe to image depth dependent focal lesions.

The change in tissue impedance due to the change in the extracellular matrix that results from the degradation of cartilage is utilized to detect degradation of articular cartilage. A probe applies a current to the articular cartilage which results in a current distribution and electric field within the cartilage, along with an associated voltage drop across the electrodes. The amplitude of this voltage drop is then measured and divided by the current applied to determine the tissue impedance. By measuring the impedance of patient tissue and comparing the detected patient impedance to a normal value for the tissue from clinically normal tissue, a determination of whether the patient tissue is degraded and the extent of degradation is possible. Preferably, the impedance is measured using a probe with interdigitated electrodes. By changing which electrodes are utilized, the wavelength of the current distribution changes, allowing the probe to image depth dependent focal lesions.

A method of producing a three dimensional section of polymerized liquid. The method includes providing a molding apparatus which includes a mold having at least one side, at least one piece of porous material adjacent to the one side of the mold and at least one support layer adjacent to the piece of porous material. The molding apparatus is clamped together and a liquid is added between the frame and the porous material. The filled molding apparatus is placed in a bath of polymerizing agent until the liquid polymerizes to form a three dimensional section.

Molding of molding polymers

A surface probe is disclosed for use in detecting the degree of degeneration in mammalian tissue. The surface probe comprises in combination with each other surface probe means for applying to a surface of the mammalian tissue a force which affects an electrokinetic parameter indicative of the amount of charged specie involved in tissue degeneration and surface detection means for detecting the electrokinetic parameter at the same surface of the mammalian tissue. A method is disclosed for detecting the degree of degeneration in mammalian tissues. Further, a system for diagnosing degenerative changes in cartilage tissue is disclosed. The system discloses a waveform generator as a source of current connected with connectors for transmitting electrical current between the generator and the surface electrodes of the surface probe and a computer connected by connectors to surface electrodes and transmitting electrodes in the surface probe for controlling electromechanical input to the surface electrodes and processing electromechanical output from the transmitting electrodes.

Probe, system and method for detecting cartilage degeneration

This invention pertains to a method of dynamically controlling the transport of a molecule across a polyelectrolyte membrane whereby chemical modulation of the electrostatic swelling forces in the polyelectrolyte membrane results in large changes in permeability and selectivity and a transmembrane electric field having electroosmotic, electrophoretic and electrostatic effects combine to allow the selective transport of the molecule across the membrane.

Dynamically controlled membrane

An electro-mechanochemical device wherein a polyelectrolyte film formed of fixed-charge, molecular groups immersed in an aqueous electrolyte comprising mobile ions is subjected to an electric field which acts to control the internal profile of mobile ions inside the polyelectrolyte film in such a way that the arrangement of the molecules that form the matrix of said film is affected.

Growing community of inventors

Lexington, MA, United States of America

Alan J Grodzinsky