The General Hospital Corporation

Other

Harvard College

Massachusetts General Hospital Corporation

Organix, Inc.

Massachusetts Institute of Technology

Ortho Pharmaceutical Corporation

Johnson Matthey Inc.

Biostream, Inc.

The Jmde Trust

Zebra Pharmaceuticals

Alan J Fischman

David R Elmaleh

Timothy M Shoup

John W Babich

Peter C Meltzer

Bertha K Madras

Robert H Rubin

Choi Sungwoon

David Baltimore

Gary James Bridger

Paul Blundell

Alun G Jones

John D Higgins, Iii

H William Strauss

Scott K Larsen

Daniel J Kroon

Claudia K Derian

Ashfaq Mahmood

Howard F Solomon

Pedro E Hernandez

Anthony J Fuccello

Choi Songwoon

Alan G Jones

One aspect of the present invention relates to a method of preparing radiofluorinated substituted alkyl, cycloalkyl, aryl, and alkenyl compounds. In a preferred embodiment, potassium fluoride-18 is used. Another aspect of the invention relates to piperazine compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the piperazine compounds contain a quaternary amine. Another aspect of the invention relates to arylphosphonium compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the phosphonium compound is a tetraaryl phosphonium salt. Another aspect of the present invention relates to a method of obtaining a positron emission image of a mammal, comprising the steps of administering to a mammal a compound of the invention, and acquiring a positron emission spectrum of the mammal.

Catalytic radiofluorination

One aspect of the present invention relates to a method of preparing radiofluorinated substituted alkyl, cycloalkyl, aryl, and alkenyl compounds. In a preferred embodiment, potassium fluoride-18 is used. Another aspect of the invention relates to arylammonium compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the ammonium compound is a tetraaryl ammonium salt. Another aspect of the invention relates to arylsulfonium compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the sulfonium compound is a triaryl sulfonium salt. Another aspect of the present invention relates to a method of obtaining a positron emission image of a mammal, comprising the steps of administering to a mammal a compound of the invention, and acquiring a positron emission spectrum of the mammal.

The present invention relates to novel modified fatty acid analogs, where a positron or gamma-emitting label is placed at a position on a fatty acid backbone and an organic substituent is substituted at the 2,3; 3,4; 4,5; 5,6 and other sequence positions of a fatty acid backbone. These novel fatty acid analogs are designed to enter the tissues of interest by the same long chain fatty acid carrier mechanism as natural fatty acids, however, functional substituents in the 2,3; 3,4; 4,5; 5,6 and other sequence positions, block the catabolic pathway, thus trapping these analogs in a virtually unmodified form in the tissues of interest.

Method for monitoring blood flow and metabolic uptake in tissue with radiolabeled alkanoic acid

Described herein are piperidine and piperazine compounds useful for treating neurodegenerated diseases characterized by a lack of dopamine neuron activity. The compounds are also useful for imaging dopamine neurons.

Diagnostic and therapeutic alkyl piperidine/piperazine compounds and process

The present invention relates to compounds and methods for imaging and treating Alzheimer's disease or an amyloidosis-associated pathological condition that utilize a novel amyloid imaging tracer for detecting amyloid deposits in a subject suffering from these conditions. In certain embodiments, the invention relates to [N-2[18F]fluoropropyl]-2-(4'-(methylamino)-phenyl)-6-hydroxybenzothiazole (F-18MHT) and dimers thereof.

Imaging tracers for early detection and treatment of amyloid plaques caused by Alzheimer's disease and related disorders

Piperidine or piperazine compounds useful for treating neurodegenerated diseases characterized by the lack of dopamine neurons activity or for imaging the dopamine neurons are provided. The compounds are characterized by the formulae: wherein:n is an integer of 1 to 6; X, Y, Zand Zcan be the same or different and are hydrogen, halo, haloalkyl, alkyl, aryl, (C-C) alkoxy, N-alkyl, (C-C) acyloxy, N-alkylene, &#x2014;SH, &#x2014;SR, wherein R is from the same group as Rand Rand can be the same or different than Rand R, amino, nitro, cyano, hydroxy, C(&#x2550;O)OR, &#x2014;C(&#x2550;O)NRR, NRR, or S(&#x2550;O)Rwhereinis 1 or 2, and Rto Rare independently hydrogen or (C-C) alkyl;

The invention relates generally to biotin-containing compounds that are useful as imaging agents and drug-delivery agents. Another aspect of the invention relates to the aforementioned compounds chelated to a metal atom. In a preferred embodiment, the metal atom is a gadolinium. Another aspect of the invention relates to a compound comprising three biotin moieties and a pharmaceutical agent covalently bound to a heterocyclic core. In certain embodiments, the pharmaceutical agent is an antibiotic, antiviral, or radionuclide. Another aspect of the present invention relates to a method of treating disease involving administering the compounds of the invention to a mammal. Another aspect of the present invention relates to a method of acquiring a magnetic resonance image using the compounds of the invention.

Polybiotin compounds of magnetic resonance imaging and drug delivery

Growing community of inventors

Boston, MA, United States of America

Alan J Fischman