Massachusetts Institute of Technology

Celsion Corporation

Boston Scientific Corporation

Other

The Titan Corporation

Medifocus, Inc.

Alan J Fenn

John Mon

Peter T Hurst

Frank Robey

Kenneth E Kolodziej

Mark Silver

Dennis Smith

Joseph M D'Arco

Jeffrey Scott Herd

Alexander Stolyarov

Siva Yegnanarayanan

Lauren Cantley

Pierre A Dufilie

Beijia Zhang

Hans Steyskal

James W Finnell, Jr

Christian D Austin

Bakari Hassan

Leonard I Parad

Sean Crowley

Jesse Mills

Adam J Chapman

Larry L Retherford

Described is a flexible thermally-drawn receive phased array antenna and antenna system and a process for making the same. The phased array antenna system includes a plurality of antenna elements and one or more low noise amplifiers (LNAs) encapsulated in a fiber such as flexible polyetherimide (PEI) fiber material. A DC bias for the LNAs and other components is provided by one or more electrically conducting wires disposed in proximity to the antenna elements and also encapsulated in the fiber. In embodiments, the antenna elements are provided as dipole antenna elements and the phased array antenna is provided as a flexible thermally-drawn linear dipole receive phased array antenna operable at UHF frequencies.

Fiber based RF phased-array antennas

A compact shallow cavity-backed discone antenna array for conformal omnidirectional antenna applications is disclosed. The antenna array comprises a plurality of discone antennas arranged in a ring array within a circular contoured conical cavity. The cavity is covered with an electrically transparent radome. The individual discone antenna elements are fed with coaxial transmission lines. Good performance is demonstrated by simulation and by experiment in terms of reflection coefficient and omnidirectional gain radiation patterns from about 960 MHz to 1220 MHz. In one embodiment, the shallow cavity-backed discone antenna array may be used as a flush-mounted antenna that conforms to the outer mold line of an aircraft.

Compact cavity-backed discone array

An inflatable antenna is disclosed herein that is capable of being deployed in space and other suitable environments and configured to improve RF performance and mechanical stability. Related methods for manufacturing and deploying such inflatable antennas are also described. The inflatable antenna can be configured to form a Gregorian dual reflector confocal parabolic antenna system when inflated. Various antenna structures, mechanisms, and manufacturing and deployment techniques are also disclosed herein that improve the precision and accuracy of RF reflective surfaces of the primary and secondary reflectors, confocal alignment of the primary and secondary reflectors, mechanical stability, and/or to improve the range of RF operation. The inflatable antenna can be manufactured and deployed with less complexity and more precision than existing inflatable antennas.

Inflatable reflector antenna and related methods

The present invention generally relates to an electromagnetic field vector sensing receive antenna array system for installation and deployment on a structure. A multipolarized array of collocated antenna elements is used to provide calibrated amplitude and phase radiation patterns with monopole, dipole, and loop modes generated from crossed loops connected to a beamformer. The invention has applications for installation and deployment on a tower, balloon, satellite for radio frequency sensing and location of low-frequency galactic emissions. The novel receive antenna array system comprises a multipolarized vector sensor antenna array. The disclosed direction-finding vector sensor can be installed and deployed on a structure and can detect and locate radio frequency emissions from galactic sources. The key system components of the receive antenna array system consist of deployable antennas, receivers, signal processing computer, and communications link.

Multipolarized vector sensor array antenna system for radio astronomy applications

The present disclosure is directed towards direction finding (DF) systems that can detect and locals a radio frequency (RF) signal (e.g. an emergency beacon) is two dimensions (i.e., azimuth and elevation). In one embodiment, a DF system comprises an array of multipolarized loop antennas coupled to a beamformer which provides monopole, dipole, and loop antenna element modal signals. The DF system may also comprise a multi-channel digital receiver system coupled to the beamformer. The multi-channel digital receiver system is configured to receive modal signals provided thereto from the beamformer which can be used for accurate two-dimensional geolocation of RF signals including, but not limited to, location of RF emergency beacon sources.

Multipolarized vector sensor array antenna system for search and rescue applications

The present invention generally relates to an electromagnetic field vector sensing receive antenna array system for installation and deployment on a structure. A multipolarized array of collocated antenna elements is used to provide calibrated amplitude and phase radiation patterns with monopole, dipole, and loop modes generated from crossed loops connected to a be beamformer. The invention has applications for installation and deployment on a tower, balloon, or satellite for radio frequency sensing and location of low-frequency galactic emissions. The novel receive antenna array system comprises a multipolarized vector sensor antenna array. The disclosed direction-finding vector sensor can be installed and deployed on a structure and can detect and locate radio frequency emissions from galactic sources. The key system components of the receive antenna array system consist of deployable antennas, receivers, signal processing computer, and communications link.

Described is a simultaneous transmit and receive antenna system having a ring array of transmit antenna elements and a receive antenna element disposed on an axis that is perpendicular to and passing through the center of the ring array. Alternatively, the ring array includes receive elements and a transmit antenna element is disposed on the axis perpendicular to the ring array. Opposite antenna elements in the ring array differ in phase by 180&#xb0; so that a radiation pattern null occurs at the antenna element at the center of the ring array. Also included are at least one ground plane and an electrically-conductive cylinder disposed on the perpendicular axis inside the ring array to provide a high degree of isolation between the transmit and receive antenna elements. The system may be configured for wireless communications, for example, according to WIFI IEEE standard 802.11 or WIMAX IEEE standard 802.16.

Simultaneous transmit and receive antenna system

A method and apparatus () of treating tissue adjacent a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema, includes injection of a drug-encapsulated within a heat-sensitive carrier, such as a liposome, within a region of tissue to be treated. The heat produced by the energy-emitting source () heats a portion of the tissue surrounding the bodily conduit to a temperature of approximately 43&#xb0; C. for a time sufficient to destroy the heated portion of the tissue. In addition, the heat produced by the energy-emitting source () activates the heat-sensitive carrier to activate the release of the encapsulated drug and the drug targets the tissue to be heated. The focused energy of the energy-emitting source together with the compression acting on the target area can assist in delivering drugs to the target area so that a natural stent has a long term efficacy.

Drug delivery

A method and apparatus of treating tissue adjacent a bodily conduit using thermotherapy, while preventing obstructions of the bodily conduit due to edema, includes injection of a drug-encapsulated within a heat-sensitive carrier, such as a liposome, within a region of tissue to be treated. The heat produced by the energy-emitting source heats a portion of the tissue surrounding the bodily conduit to a temperature of approximately 43&#xb0; C. for a time sufficient to destroy the heated portion of the tissue. In addition, the heat produced by the energy-emitting source activates the heat-sensitive carrier to activate the release of the encapsulated drug and the drug targets the tissue to be heated. The focused energy of the energy-emitting source together with the compression acting on the target area can assist in delivering drugs to the target area so that a natural stent has a long term efficacy.

Method and apparatus treating tissue adjacent a bodily conduit with thermocompression and drugs

A monopole phased array thermotherapy applicator radiating radiofrequency energy for inducing a temperature rise in a target within a body includes a plurality of monopole elements each for transmitting electric-field radiation; a metallic waveguide with an RF reflecting ground plane surface with a plurality of circular holes for mounting the monopole elements where the metallic waveguide forms an aperture for receiving a body to be treated; a waveform generator providing a source of electric field coupled to each monopole radiating element through a respective phase and power weighting network; at least one electric field probe positioned on a skin surface of the body for detecting electric field radiation from the plurality of monopole elements; and a controller circuit coupled to the electric field probe received feedback signals to adjust the phase and power delivered to the plurality of monopole elements so that one or more adaptive nulls are formed on the surface of the body and a focus is formed at the target tissue to be treated with thermotherapy.

Monopole phased array thermotherapy applicator for deep tumor therapy

Improvements in safety and efficacy for externally focused adaptive phased array microwave thermotherapy (hyperthermia) for treatment of cancer and benign conditions of an organ or an appendage are described. In order to reduce blood flow thereby accumulating additional equivalent thermal dose following the step of heating an organ or appendage by irradiating microwaves at the organ or appendage, the step of compressing the organ or appendage following the heating step is added to thermotherapy treatment. In a preferred embodiment, the organ is the prostate and periodic prostate compression is employed to reduce the prostate blood flow thereby allowing chemotherapy, thermosensitive liposome-encapsulated chemotherapy, or gene therapy to accumulate in the prostate region during thermotherapy. Doppler ultrasound imaging may be used to measure tumor blood flow rate and then serve as real-time feedback to assist in adjusting the amount of balloon catheter inflation and to assess damage to the tumor vasculature during the treatment.

System and method for heating the prostate gland to treat and prevent the growth and spread of prostate tumor

A method and apparatus that increases safety when employing externally focused adaptive phased array microwave thermotherapy (hyperthermia) for breast cancer treatment include microwave absorbing pads and metallic shielding to prevent undesired or stray surface tissue heating and to cushion the breast from mechanical pressure during breast compression. The microwave absorbing pads are attached on the top of the microwave waveguide thermotherapy applicators and on top of the breast compression paddles. A metallic-shielding strip mounted across the top portion of the microwave applicator aperture acts to block microwave radiation from illuminating the base of the breast and chest wall area. The patient treatment table utilizes a metallic shield to shield the body from stray microwave radiation. Combined E-field and temperature sensors within a single catheter are used to require only a single minimally invasive skin entry point for E-field focusing and measurement of the tumor temperature. Breast compression is maintained for a period of time following microwave-induced heating to accumulate additional equivalent thermal dose. Treatments incorporating the safety improvements include thermotherapy for early-stage breast carcinomas, locally advanced breast cancer, ductal carcinoma in-situ, and benign breast lesions.

Method for improved safety in externally focused microwave thermotherapy for treating breast cancer

A method for treating cancerous or benign conditions of a body or organ employs selective irradiation of the body tissue with energy. The method includes the steps of monitoring temperatures of the skin surface adjacent the body, positioning at least one energy applicator around the body, delivering energy to the at least one energy applicator to selectively irradiate the body tissue with energy and treat at least one of cancerous and benign conditions of the body, adjusting the level of power to be delivered to the at least one energy applicator during treatment based on the monitored skin temperatures, monitoring the energy delivered to the at least one energy applicator, determining total energy delivered to the at least one energy applicator, and completing the treatment when the desired total energy dose has been delivered by the at least one energy applicator to the body.

Thermotherapy method for treatment and prevention of cancer in male and female patients and cosmetic ablation of tissue

A method for treating cancerous or benign conditions of an organ includes the steps of inserting an E-field probe sensor to a depth in the organ tissue, monitoring temperatures of the skin surface adjacent the organ, positioning two or more energy applicators around the organ, setting the initial relative phase delivered to each energy applicator to focus the energy at the E-field probe positioned in the organ tissue, delivering energy to the applicators to selectively irradiate the organ tissue, adjusting the power level to be delivered to each applicator during treatment based on the monitored skin temperatures, monitoring the energy delivered to the applicators, determining total energy delivered to the applicators and displaying the total energy in real time during the treatment, and completing the treatment when the desired total energy dose has been delivered by the energy applicators to the organ. Either focused or non-focused may be employed.

Growing community of inventors

Wayland, MA, United States of America

Alan J Fenn