Bioverativ Therapeutics Inc.

Biogen Hemophilia Inc.

Alan J Bitoni

Robert T Peters

Susan C Low

Haiyan Jiang

Glenn Pierce

Adam Robert Mezo

Jennifer A Dumont

Daniel S Rivera

Jurg Sommer

Alvin Luk

Byron McKinney

Matt Ottmer

Karen Nugent

Lian Li

James M Stattel

Adam R Mezo

The present invention provides methods of administering Factor VIII (processed FVIII, single chain FVIII, or a combination thereof); methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.

Factor VIII chimeric and hybrid polypeptides, and methods of use thereof

The invention relates to a chimeric monomer-dimer hybrid protein wherein the protein comprises a first and a second polypeptide chain, the first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and the second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.

Immunoglobulin chimeric monomer-dimer hybrids

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Acton, MA, United States of America

Alan J Bitoni