Georgetown University

Other

Medicis Corporation

Alan I Faden

Alan P Kozikowski

Gian Luca Araldi

The present invention provides 4-substituted-2-azetidinone compounds, bicyclic 2-5-diketopiperazine compounds, and pharmaceutical compositions thereof that are potent, safe and effective neuroprotective agents. Due to their strong central nervous system (CNS) activity, the compounds can be used to enhance memory and to treat a variety of neurological disorders. The compounds are particularly useful for treating neurological disorders caused by, or associated with, CNS trauma.

Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders

A series of novel thyrotropin-releasing hormone analogs wherein the C-terminal prolineamide moiety has been preserved, the N-terminal moiety comprises one of five different ring structures and the histidyl moiety is substituted with CF.sub.3, NO.sub.2 or a halogen. A method of use of the analog for the treatment of neurologic disorders is also provided.

Thyrotropin-releasing hormone analogs and method of use

The present invention involves methods of inducing opiate-receptor antagonistic activity in a patient suffering from ischemic or traumatic central nervous system injury by administering to said patient an effective amount of an opiate-receptor antagonist having enhanced activity at the kappa-opiate receptor suitable to permit the induction of opiate-receptor antogonistic activity.

Central nervous system injury treatment with opiate-receptor antagonist

The present invention involves methods of inducing opiate-receptor antagonistic activity in a patient suffering from ischemic or traumatic brain injury by administering to said patient an effective amount of an opiate-receptor antagonist having enhanced activity at the kappa-opiate receptor suitable to permit the induction of opiate-receptor antagonistic activity.

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Mill Valley, CA, United States of America

Alan I Faden