American Home Products Corporation

Wyeth

Other

Alan Howard Katz

Christopher A Demerson

Scott Christian Mayer

Leslie G Humber

John Anthony Butera

Craig E Caufield

Robert E McDevitt

Alexander Greenfield

Joseph R Lennox

Eric Gould Gundersen

Lisa Marie Havran

Brian Alexander McKittrick

Russell Graceffa

Russell F Graceffa

This invention provides compounds of Formula I having the structureor a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.

2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia

This invention provides compounds of Formula I having the structurewherein:

Substituted naphthoic acid derivatives useful in the treatment of insulin resistance and hyperglycemia

This invention provides compounds of Formula I having the structure

Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at positions 5, 6, 7 and 8. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.

Substituted 1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acids

Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1-, 4-, 5-, 6-, 7- and 8- are disclosed. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.

Preparation of tryptophols

Substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids

Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing substituents in position 1-,5-,6-, 7- and 8- are disclosed. The derivatives are useful anti-inflammatory and/or analgesic agents. Methods for their preparation and use are also disclosed.

Substituted-8-alkenyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic

Production of indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at positions 5, 6, 7 and 8. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.

Production of substituted 1,3,4,9-tetrahydropyrano(3,4-B)indole-1-acetic

Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing substituents in position 1-, 5-, 6-, 7- and 8- are disclosed. The derivatives are useful anti-inflammatory and/or analgesic agents. Methods for their preparation and use are also disclosed.

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Lawrenceville, NJ, United States of America

Alan Howard Katz